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Ninj2 ninjurin 2 [ Mus musculus (house mouse) ]

Gene ID: 29862, updated on 19-Feb-2023

Summary

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Official Symbol
Ninj2provided by MGI
Official Full Name
ninjurin 2provided by MGI
Primary source
MGI:MGI:1352751
See related
Ensembl:ENSMUSG00000041377 AllianceGenome:MGI:1352751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human NINJ2 (ninjurin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 1.9), cerebellum adult (RPKM 1.1) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Ninj2 in Genome Data Viewer
Location:
6; 6 F1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120070341..120177300)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120093380..120200531)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene microRNA 706 Neighboring gene predicted gene, 25327 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3 Neighboring gene coiled-coil domain containing 77 Neighboring gene lysine (K)-specific demethylase 5A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway. Wang Y, et al. Metabolism, 2023 Mar. PMID 36549436
  2. NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling. Peng H, et al. Obesity (Silver Spring), 2023 Jan. PMID 36504350
  3. Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling. Sun Y, et al. Theranostics, 2022. PMID 36438492, Free PMC Article
  4. Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors. Sun Y, et al. Adv Sci (Weinh), 2022 Jan. PMID 34787377, Free PMC Article
  5. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. Araki T, et al. J Neurosci, 2000 Jan 1. PMID 10627596, Free PMC Article

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway.
    Title: Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway.
  2. NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling.
    Title: NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling.
  3. Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.
    Title: Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.
  4. Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
    Title: Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC143502

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ninjurin-2
Names
nerve injury-induced protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347432.2 → NP_001334361.1  ninjurin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC156951
    Consensus CDS
    CCDS85148.1
    UniProtKB/TrEMBL
    F8WIJ3
    Related
    ENSMUSP00000046306.6, ENSMUST00000035244.6

  2. NM_016718.3 → NP_057927.1  ninjurin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC113092, AC156951
    Consensus CDS
    CCDS39612.1
    UniProtKB/Swiss-Prot
    Q9JL89
    UniProtKB/TrEMBL
    Q3TQA7
    Related
    ENSMUSP00000108331.3, ENSMUST00000112711.9
    Conserved Domains (1) summary
    pfam04923
    Location:26 → 126
    Ninjurin; Ninjurin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    120070341..120177300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166209.1 → XP_036022102.1  ninjurin-2 isoform X1

    Conserved Domains (1) summary
    pfam04923
    Location:11 → 111
    Ninjurin

  2. XM_006506224.5 → XP_006506287.1  ninjurin-2 isoform X1

    Conserved Domains (1) summary
    pfam04923
    Location:11 → 111
    Ninjurin

  3. XM_006506223.5 → XP_006506286.1  ninjurin-2 isoform X1

    Conserved Domains (1) summary
    pfam04923
    Location:11 → 111
    Ninjurin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL89.1 GenPept UniProtKB/Swiss-Prot:Q9JL89

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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