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NFYC nuclear transcription factor Y subunit gamma [ Homo sapiens (human) ]

Gene ID: 4802, updated on 6-Jan-2019

Summary

Official Symbol
NFYCprovided by HGNC
Official Full Name
nuclear transcription factor Y subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:7806
See related
Ensembl:ENSG00000066136 MIM:605344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A
Summary
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.6), heart (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See NFYC in Genome Data Viewer
Location:
1p34.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (40691570..40771603)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41157242..41237275)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene uncharacterized LOC105378675 Neighboring gene uncharacterized LOC105378674 Neighboring gene NFYC antisense RNA 1 Neighboring gene microRNA 30e Neighboring gene microRNA 30c-1 Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene RNA, 7SL, cytoplasmic 326, pseudogene Neighboring gene GATA motif-containing MPRA enhancers 242 and 247

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45775, DKFZp667G242

Gene Ontology Provided by GOA

Component Evidence Code Pubs
CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit gamma
Names
CAAT box DNA-binding protein subunit C
CCAAT binding factor subunit C
CCAAT transcription binding factor subunit gamma
histone H1 transcription factor large subunit 2A
nuclear transcription factor Y subunit C
nuclear transcription factor Y, gamma
transactivator HSM-1
transactivator HSM-1/2
transcription factor NF-Y, C subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142587.1NP_001136059.1  nuclear transcription factor Y subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001136059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) has the same N- and C- termini but lacks an internal segment and one residue near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AB208975, AL354914, D89986, DC391720
    Consensus CDS
    CCDS44121.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000408867.2, ENST00000456393.6
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  2. NM_001142588.1NP_001136060.1  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001136060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC119677, AK300774, AL354914, D89986, DC391720
    Consensus CDS
    CCDS44120.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000396620.2, ENST00000425457.6
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  3. NM_001142589.1NP_001136061.1  nuclear transcription factor Y subunit gamma isoform 4

    See identical proteins and their annotated locations for NP_001136061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has the same N- and C- termini but lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AB208975, AK301385, D89986, DC391720
    Consensus CDS
    CCDS44123.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000408315.2, ENST00000427410.6
    Conserved Domains (1) summary
    cl28542
    Location:1785
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  4. NM_001142590.1NP_001136062.1  nuclear transcription factor Y subunit gamma isoform 5

    See identical proteins and their annotated locations for NP_001136062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate splice pattern in the 5' UTR, lacks an alternate exon in the 3' coding region, and uses an alternate splice site in the central coding region, compared to variant 1. the resulting isoform (5) has the same N- and C- termini but lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC119677, AK127677, AL031289, AL354914, D89986, DC297902
    Consensus CDS
    CCDS44122.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000361737.1, ENST00000372653.5
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  5. NM_001308114.1NP_001295043.1  nuclear transcription factor Y subunit gamma isoform 6

    See identical proteins and their annotated locations for NP_001295043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice acceptor site in the 3' terminal exon compared to variant 1. The resulting isoform (6) has the same N- and C- termini but contains an additional segment in the 3' coding region, compared to isoform 1.
    Source sequence(s)
    AF191744, AK000346, BP230898, BU634106
    Consensus CDS
    CCDS81305.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000312617.5, ENST00000308733.9
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  6. NM_001308115.1NP_001295044.1  nuclear transcription factor Y subunit gamma isoform 7

    See identical proteins and their annotated locations for NP_001295044.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks an alternate in-frame exon in the central coding region, and uses an alternate in-frame splice acceptor site in the 3' terminal exon compared to variant 1. The resulting isoform (7) has the same N- and C- termini but lacks a segment in the central coding region, and contains an additional segment in the 3' coding region, compared to isoform 1.
    Source sequence(s)
    AK000346, BP230898, BU634106
    Consensus CDS
    CCDS81306.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000361736.1, ENST00000372652.5
    Conserved Domains (1) summary
    pfam00808
    Location:42105
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  7. NM_014223.4NP_055038.2  nuclear transcription factor Y subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_055038.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C- termini but lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC119677, BC005003, D89986, DC391720
    Consensus CDS
    CCDS455.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000404427.3, ENST00000447388.7
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    40691570..40771603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001365.2XP_016856854.1  nuclear transcription factor Y subunit gamma isoform X3

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  2. XM_006710661.2XP_006710724.1  nuclear transcription factor Y subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006710724.1

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    pfam00808
    Location:42105
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  3. XM_005270894.1XP_005270951.1  nuclear transcription factor Y subunit gamma isoform X3

    See identical proteins and their annotated locations for XP_005270951.1

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  4. XM_017001367.1XP_016856856.1  nuclear transcription factor Y subunit gamma isoform X5

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  5. XM_017001368.1XP_016856857.1  nuclear transcription factor Y subunit gamma isoform X9

    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000361734.1, ENST00000372651.5
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  6. XM_024447354.1XP_024303122.1  nuclear transcription factor Y subunit gamma isoform X3

    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  7. XM_017001369.1XP_016856858.1  nuclear transcription factor Y subunit gamma isoform X9

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  8. XM_011541516.1XP_011539818.1  nuclear transcription factor Y subunit gamma isoform X3

    See identical proteins and their annotated locations for XP_011539818.1

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  9. XM_017001364.2XP_016856853.1  nuclear transcription factor Y subunit gamma isoform X6

  10. XM_017001366.2XP_016856855.1  nuclear transcription factor Y subunit gamma isoform X8

  11. XM_024447356.1XP_024303124.1  nuclear transcription factor Y subunit gamma isoform X7

    Conserved Domains (1) summary
    cl28542
    Location:87193
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  12. XM_024447357.1XP_024303125.1  nuclear transcription factor Y subunit gamma isoform X9

    Related
    ENSP00000414299.2, ENST00000440226.7
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  13. XM_024447355.1XP_024303123.1  nuclear transcription factor Y subunit gamma isoform X3

    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  14. XM_006710662.3XP_006710725.3  nuclear transcription factor Y subunit gamma isoform X10

    Conserved Domains (1) summary
    cl28542
    Location:103209
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  15. XM_005270895.4XP_005270952.4  nuclear transcription factor Y subunit gamma isoform X2

    Conserved Domains (1) summary
    cl28542
    Location:103209
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  16. XM_011541517.2XP_011539819.1  nuclear transcription factor Y subunit gamma isoform X4

    Conserved Domains (1) summary
    pfam00808
    Location:42105
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  17. XM_006710660.3XP_006710723.2  nuclear transcription factor Y subunit gamma isoform X5

    See identical proteins and their annotated locations for XP_006710723.2

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  18. XM_006710658.3XP_006710721.2  nuclear transcription factor Y subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006710721.2

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    pfam00808
    Location:42105
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
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