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Nfyc nuclear transcription factor-Y gamma [ Mus musculus (house mouse) ]

Gene ID: 18046, updated on 9-Mar-2023

Summary

Official Symbol
Nfycprovided by MGI
Official Full Name
nuclear transcription factor-Y gammaprovided by MGI
Primary source
MGI:MGI:107901
See related
Ensembl:ENSMUSG00000032897 AllianceGenome:MGI:107901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; limb; molar; and nervous system. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 46.0), thymus adult (RPKM 39.2) and 28 other tissues See more
Orthologs
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Genomic context

See Nfyc in Genome Data Viewer
Location:
4 D2.1; 4 56.52 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120614632..120688776, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120757435..120831579, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Neighboring gene potassium voltage-gated channel, subfamily Q, member 4 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene microRNA 30f Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit gamma
Names
CAAT box DNA-binding protein subunit C
nuclear transcription factor Y subunit C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048168.2NP_001041633.1  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001041633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5 and 6 encode the same isoform (1).
    Source sequence(s)
    AB006181, AK011327, BC053723, BE647422, DV650959
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    P70353, Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15, Q7TPS7
    Related
    ENSMUSP00000112610.2, ENSMUST00000118902.8
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  2. NM_001277095.1NP_001264024.1  nuclear transcription factor Y subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001264024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB006181, AK011327, AL606904, BE647422
    UniProtKB/Swiss-Prot
    P70353
    UniProtKB/TrEMBL
    Q3U114
    Conserved Domains (1) summary
    cl23735
    Location:4260
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
  3. NM_001357192.1NP_001344121.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5 and 6 encode the same isoform (1).
    Source sequence(s)
    AB006181, AK011327, AL606904, BE647422
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15
    Related
    ENSMUSP00000112810.2, ENSMUST00000120779.8
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  4. NM_001357193.1NP_001344122.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5 and 6 encode the same isoform (1).
    Source sequence(s)
    AB006181, AK011327, AL606904, BE647422, BY005484
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  5. NM_001357194.1NP_001344123.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5 and 6 encode the same isoform (1).
    Source sequence(s)
    AB006181, AK011327, AL606904, BE647422, BY005484
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  6. NM_008692.4NP_032718.2  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_032718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the llonger isoform (1). Variants 1, 2, 4, 5 and 6 encode the same isoform (1).
    Source sequence(s)
    AB006181, AK011327, AL606904, BE647422
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    P70353, Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15
    Related
    ENSMUSP00000047441.6, ENSMUST00000043429.12
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120614632..120688776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502851.5XP_006502914.1  nuclear transcription factor Y subunit gamma isoform X4

    Conserved Domains (1) summary
    COG5208
    Location:2361
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  2. XM_006502849.5XP_006502912.1  nuclear transcription factor Y subunit gamma isoform X2

    UniProtKB/TrEMBL
    A0A6P7QY92, A0A8C6GV52
    Conserved Domains (1) summary
    COG5208
    Location:3699
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  3. XM_030253306.2XP_030109166.1  nuclear transcription factor Y subunit gamma isoform X3

    Conserved Domains (1) summary
    COG5208
    Location:1798
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  4. XM_036163816.1XP_036019709.1  nuclear transcription factor Y subunit gamma isoform X2

    UniProtKB/TrEMBL
    A0A6P7QY92, A0A8C6GV52
    Conserved Domains (1) summary
    COG5208
    Location:3699
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  5. XM_030253305.2XP_030109165.1  nuclear transcription factor Y subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  6. XM_030253307.1XP_030109167.1  nuclear transcription factor Y subunit gamma isoform X4

    Conserved Domains (1) summary
    COG5208
    Location:2361
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  7. XM_036163814.1XP_036019707.1  nuclear transcription factor Y subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    Q6GU21
    UniProtKB/TrEMBL
    A0A6P5PKB1, A0A8C6GV15
    Related
    ENSMUSP00000095516.6, ENSMUST00000097906.12
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RNA

  1. XR_003954890.2 RNA Sequence

  2. XR_003954891.2 RNA Sequence

  3. XR_004941831.1 RNA Sequence