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Nfyc nuclear transcription factor-Y gamma [ Mus musculus (house mouse) ]

Gene ID: 18046, updated on 7-Apr-2025

Summary

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Official Symbol
Nfycprovided by MGI
Official Full Name
nuclear transcription factor-Y gammaprovided by MGI
Primary source
MGI:MGI:107901
See related
Ensembl:ENSMUSG00000032897 AllianceGenome:MGI:107901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; limb; molar; and nervous system. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 46.0), thymus adult (RPKM 39.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nfyc in Genome Data Viewer
Location:
4 D2.1; 4 56.52 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120614632..120688776, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120757435..120831579, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10253 Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Neighboring gene potassium voltage-gated channel, subfamily Q, member 4 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene microRNA 30f Neighboring gene STARR-seq mESC enhancer starr_11254 Neighboring gene STARR-positive B cell enhancer ABC_E3507 Neighboring gene STARR-seq mESC enhancer starr_11255 Neighboring gene STARR-seq mESC enhancer starr_11256 Neighboring gene STARR-positive B cell enhancer mm9_chr4:120523542-120523843 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene STARR-positive B cell enhancer ABC_E4657 Neighboring gene STARR-positive B cell enhancer ABC_E4658 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Binding of NF-Y transcription factor to one of the cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor. Orita T, et al. J Biol Chem, 1997 Sep 12. PMID 9287329
  2. Transforming growth factor β1 (TGF-β1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells. Castro NE, et al. J Biol Chem, 2014 Oct 17. PMID 25204661, Free PMC Article
  3. Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors. Oldfield AJ, et al. Mol Cell, 2014 Sep 4. PMID 25132174, Free PMC Article
  4. Nuclear factor Y (NF-Y) and cellular senescence. Matuoka K, et al. Exp Cell Res, 1999 Dec 15. PMID 10585259
  5. Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox. Nakshatri H, et al. J Biol Chem, 1996 Nov 15. PMID 8910521

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NF-Y binds to p73 and transcriptionally regulates platelet derived growth factor beta receptor
    Title: p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-DNA complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
nuclear transcription factor Y subunit gamma
Names
CAAT box DNA-binding protein subunit C
nuclear transcription factor Y subunit C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048168.3 → NP_001041633.1  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001041633.1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000112610.2, ENSMUST00000118902.8
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  2. NM_001277095.2 → NP_001264024.1  nuclear transcription factor Y subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001264024.1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q3U114
    Conserved Domains (1) summary
    cl23735
    Location:42 → 60
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

  3. NM_001357192.2 → NP_001344121.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000112810.2, ENSMUST00000120779.8
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  4. NM_001357193.2 → NP_001344122.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  5. NM_001357194.2 → NP_001344123.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  6. NM_001421278.1 → NP_001408207.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7

  7. NM_001421279.1 → NP_001408208.1  nuclear transcription factor Y subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  8. NM_001421282.1 → NP_001408211.1  nuclear transcription factor Y subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  9. NM_001421285.1 → NP_001408214.1  nuclear transcription factor Y subunit gamma isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  10. NM_001421286.1 → NP_001408215.1  nuclear transcription factor Y subunit gamma isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

  11. NM_001421287.1 → NP_001408216.1  nuclear transcription factor Y subunit gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  12. NM_001421288.1 → NP_001408217.1  nuclear transcription factor Y subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  13. NM_001421289.1 → NP_001408218.1  nuclear transcription factor Y subunit gamma isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  14. NM_001421290.1 → NP_001408219.1  nuclear transcription factor Y subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  15. NM_001421291.1 → NP_001408220.1  nuclear transcription factor Y subunit gamma isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

  16. NM_001421292.1 → NP_001408221.1  nuclear transcription factor Y subunit gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

  17. NM_001421293.1 → NP_001408222.1  nuclear transcription factor Y subunit gamma isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

  18. NM_001421294.1 → NP_001408223.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7

  19. NM_001421295.1 → NP_001408224.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7

  20. NM_001421296.1 → NP_001408225.1  nuclear transcription factor Y subunit gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7

  21. NM_008692.5 → NP_032718.2  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_032718.2

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000047441.6, ENSMUST00000043429.12
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RNA

  1. NR_185291.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

  2. NR_185292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120614632..120688776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253307.1 → XP_030109167.1  nuclear transcription factor Y subunit gamma isoform X4

    Conserved Domains (1) summary
    COG5208
    Location:23 → 61
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  2. XM_036163814.1 → XP_036019707.1  nuclear transcription factor Y subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000095516.6, ENSMUST00000097906.12
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RNA

  1. XR_004941831.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70353.2 GenPept UniProtKB/Swiss-Prot:P70353

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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