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Nfyc nuclear transcription factor-Y gamma [ Mus musculus (house mouse) ]

Gene ID: 18046, updated on 6-Jun-2024

Summary

Official Symbol
Nfycprovided by MGI
Official Full Name
nuclear transcription factor-Y gammaprovided by MGI
Primary source
MGI:MGI:107901
See related
Ensembl:ENSMUSG00000032897 AllianceGenome:MGI:107901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; limb; molar; and nervous system. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 46.0), thymus adult (RPKM 39.2) and 28 other tissues See more
Orthologs
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Genomic context

See Nfyc in Genome Data Viewer
Location:
4 D2.1; 4 56.52 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120614632..120688776, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120757435..120831579, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10253 Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Neighboring gene potassium voltage-gated channel, subfamily Q, member 4 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene microRNA 30f Neighboring gene STARR-seq mESC enhancer starr_11254 Neighboring gene STARR-positive B cell enhancer ABC_E3507 Neighboring gene STARR-seq mESC enhancer starr_11255 Neighboring gene STARR-seq mESC enhancer starr_11256 Neighboring gene STARR-positive B cell enhancer mm9_chr4:120523542-120523843 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene STARR-positive B cell enhancer ABC_E4657 Neighboring gene STARR-positive B cell enhancer ABC_E4658 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit gamma
Names
CAAT box DNA-binding protein subunit C
nuclear transcription factor Y subunit C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048168.3NP_001041633.1  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001041633.1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000112610.2, ENSMUST00000118902.8
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  2. NM_001277095.2NP_001264024.1  nuclear transcription factor Y subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001264024.1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q3U114
    Conserved Domains (1) summary
    cl23735
    Location:4260
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
  3. NM_001357192.2NP_001344121.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000112810.2, ENSMUST00000120779.8
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  4. NM_001357193.2NP_001344122.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  5. NM_001357194.2NP_001344123.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  6. NM_001421278.1NP_001408207.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
  7. NM_001421279.1NP_001408208.1  nuclear transcription factor Y subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  8. NM_001421282.1NP_001408211.1  nuclear transcription factor Y subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  9. NM_001421285.1NP_001408214.1  nuclear transcription factor Y subunit gamma isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  10. NM_001421286.1NP_001408215.1  nuclear transcription factor Y subunit gamma isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
  11. NM_001421287.1NP_001408216.1  nuclear transcription factor Y subunit gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  12. NM_001421288.1NP_001408217.1  nuclear transcription factor Y subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  13. NM_001421289.1NP_001408218.1  nuclear transcription factor Y subunit gamma isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  14. NM_001421290.1NP_001408219.1  nuclear transcription factor Y subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  15. NM_001421291.1NP_001408220.1  nuclear transcription factor Y subunit gamma isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
  16. NM_001421292.1NP_001408221.1  nuclear transcription factor Y subunit gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
  17. NM_001421293.1NP_001408222.1  nuclear transcription factor Y subunit gamma isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
  18. NM_001421294.1NP_001408223.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
  19. NM_001421295.1NP_001408224.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
  20. NM_001421296.1NP_001408225.1  nuclear transcription factor Y subunit gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    UniProtKB/TrEMBL
    Q7TPS7
  21. NM_008692.5NP_032718.2  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_032718.2

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
    Consensus CDS
    CCDS18594.1
    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000047441.6, ENSMUST00000043429.12
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RNA

  1. NR_185291.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924
  2. NR_185292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL606924

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120614632..120688776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253307.1XP_030109167.1  nuclear transcription factor Y subunit gamma isoform X4

    Conserved Domains (1) summary
    COG5208
    Location:2361
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  2. XM_036163814.1XP_036019707.1  nuclear transcription factor Y subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    O35088, P70353, Q6GU21
    UniProtKB/TrEMBL
    Q7TPS7
    Related
    ENSMUSP00000095516.6, ENSMUST00000097906.12
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RNA

  1. XR_004941831.1 RNA Sequence