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NFATC4 nuclear factor of activated T cells 4 [ Homo sapiens (human) ]

Gene ID: 4776, updated on 24-Nov-2020

Summary

Official Symbol
NFATC4provided by HGNC
Official Full Name
nuclear factor of activated T cells 4provided by HGNC
Primary source
HGNC:HGNC:7778
See related
Ensembl:ENSG00000100968 MIM:602699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NFAT3; NF-AT3; NF-ATC4
Summary
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Broad expression in ovary (RPKM 15.2), endometrium (RPKM 13.8) and 22 other tissues See more
Orthologs

Genomic context

See NFATC4 in Genome Data Viewer
Location:
14q12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24366911..24379604)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24834885..24848810)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 4 Neighboring gene receptor interacting serine/threonine kinase 3 Neighboring gene NYN domain and retroviral integrase containing Neighboring gene KH and NYN domain containing Neighboring gene cerebellin 3 precursor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
env Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT PubMed
Nef nef HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef PubMed
Tat tat The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes PubMed
tat Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2 PubMed
tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT PubMed
tat HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR PubMed
tat HIV-1 Tat enhances IL-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif PubMed
Vpr vpr HIV-1 Vpr upregulates NFAT-directed gene expression PubMed
Vpu vpu HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
brain-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular respiration IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionomycin IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chromatin binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pri-miRNA transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synapse maturation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISA
Inferred from Sequence Alignment
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear factor of activated T-cells, cytoplasmic 4
Names
T-cell transcription factor NFAT3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136022.3NP_001129494.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 1

    See identical proteins and their annotated locations for NP_001129494.1

    Status: REVIEWED

    Source sequence(s)
    BC053855, DC403050, EU887634
    Consensus CDS
    CCDS45089.1
    UniProtKB/Swiss-Prot
    Q14934
    Related
    ENSP00000388910.2, ENST00000413692.6
    Conserved Domains (2) summary
    cd07881
    Location:470643
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:648748
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  2. NM_001198965.2NP_001185894.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 3

    See identical proteins and their annotated locations for NP_001185894.1

    Status: REVIEWED

    Source sequence(s)
    BC053855, DC318153, EU887634, EU887642
    Consensus CDS
    CCDS55910.1
    UniProtKB/Swiss-Prot
    Q14934
    Related
    ENSP00000451151.1, ENST00000554050.5
    Conserved Domains (2) summary
    cd07881
    Location:407580
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:585685
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  3. NM_001198966.2NP_001185895.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 4

    See identical proteins and their annotated locations for NP_001185895.1

    Status: REVIEWED

    Source sequence(s)
    AK302271, BC053855, BG723088, EU887632, EU887634
    Consensus CDS
    CCDS55911.1
    UniProtKB/Swiss-Prot
    Q14934
    Related
    ENSP00000452349.1, ENST00000553879.5
    Conserved Domains (2) summary
    cd07881
    Location:337510
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:515615
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  4. NM_001198967.3NP_001185896.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 5

    See identical proteins and their annotated locations for NP_001185896.1

    Status: REVIEWED

    Source sequence(s)
    BC053855, DC403050, EU887633, EU887640
    Consensus CDS
    CCDS55909.1
    UniProtKB/Swiss-Prot
    Q14934
    Related
    ENSP00000452039.1, ENST00000554591.5
    Conserved Domains (2) summary
    cd07881
    Location:470643
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:648748
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  5. NM_001288802.2NP_001275731.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 6

    See identical proteins and their annotated locations for NP_001275731.1

    Status: REVIEWED

    Source sequence(s)
    AK310433, AL096870, BC053855, EU887634
    Consensus CDS
    CCDS73625.1
    UniProtKB/Swiss-Prot
    Q14934
    Related
    ENSP00000396788.3, ENST00000422617.7
    Conserved Domains (2) summary
    cd07881
    Location:395568
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:573673
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  6. NM_001320043.2NP_001306972.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL096870, BC008857, BC053855, DC403050, EU887632
    UniProtKB/Swiss-Prot
    Q14934
    Conserved Domains (2) summary
    cd07881
    Location:470643
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:648748
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  7. NM_001363681.1NP_001350610.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL096870, EU887644
    Consensus CDS
    CCDS86380.1
    Related
    ENSP00000450686.1, ENST00000555453.5
    Conserved Domains (3) summary
    cd07881
    Location:395568
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:573673
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl26464
    Location:202401
    Atrophin-1; Atrophin-1 family
  8. NM_001363682.1NP_001350611.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL096870, EU887645
    Consensus CDS
    CCDS86379.1
    Related
    ENSP00000451454.1, ENST00000556169.5
    Conserved Domains (3) summary
    cd07881
    Location:395568
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:573673
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl26464
    Location:202401
    Atrophin-1; Atrophin-1 family
  9. NM_004554.5NP_004545.2  nuclear factor of activated T-cells, cytoplasmic 4 isoform 2

    See identical proteins and their annotated locations for NP_004545.2

    Status: REVIEWED

    Source sequence(s)
    BC008857, BC053855, DB372155, DC318153
    Consensus CDS
    CCDS9629.1
    UniProtKB/Swiss-Prot
    Q14934
    Related
    ENSP00000250373.4, ENST00000250373.9
    Conserved Domains (2) summary
    cd07881
    Location:407580
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:585685
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24366911..24379604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    667889..680582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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