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NFATC1 nuclear factor of activated T cells 1 [ Homo sapiens (human) ]

Gene ID: 4772, updated on 22-Feb-2020

Summary

Official Symbol
NFATC1provided by HGNC
Official Full Name
nuclear factor of activated T cells 1provided by HGNC
Primary source
HGNC:HGNC:7775
See related
Ensembl:ENSG00000131196 MIM:600489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NFAT2; NFATc; NF-ATC; NF-ATc1.2
Summary
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Expression
Broad expression in lymph node (RPKM 7.4), spleen (RPKM 6.0) and 24 other tissues See more
Orthologs

Genomic context

See NFATC1 in Genome Data Viewer
Location:
18q23
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (79395930..79529323)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (77155772..77289323)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 9B (putative) Neighboring gene uncharacterized LOC105372226 Neighboring gene histidine-rich protein PFHRP-II-like Neighboring gene uncharacterized LOC107985163 Neighboring gene uncharacterized LOC101927897 Neighboring gene uncharacterized LOC107985162 Neighboring gene uncharacterized LOC102723506 Neighboring gene uncharacterized LOC284240 Neighboring gene uncharacterized LOC105372228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
env Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT PubMed
Nef nef HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef PubMed
nef HIV-1 Nef-induced priming of TCR signaling pathways increases the number of cells expressing the transcription factors NF-kappaB and NFAT after TCR stimulation PubMed
nef Nef-mediated super-induction of IL-2 reflects the activation of both NFAT and NFkappaB in response to CD3 or CD28 stimulation PubMed
nef HIV-1 Nef expression significantly downregulates the level of plasma membrane GM1 in unstimulated T cells, which inhibits the activation of nuclear factor of activated T-cells (NF-AT) PubMed
Tat tat The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes PubMed
tat HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR PubMed
tat Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2 PubMed
tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT PubMed
tat HIV-1 Tat enhances IL-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif PubMed
tat NF-ATc synergizes with NF-kappa B and HIV-1 Tat in transcriptional activation of the HIV-1 LTR promoter and enhances HIV-1 replication in T cells PubMed
Vpr vpr HIV-1 Vpr induces NFAT in primary T cells and macrophages PubMed
vpr HIV-1 Vpr stimulates early NFAT activation PubMed
vpr HIV-1 Vpr upregulates NFAT-directed gene expression PubMed
Vpu vpu HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef PubMed
reverse transcriptase gag-pol NFATc facilitates HIV-1 RT reverse transcription activity and enhances HIV-1 infectivity in human T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138448

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
FK506 binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase p38 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
aortic valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
pulmonary valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear factor of activated T-cells, cytoplasmic 1
Names
NFAT transcription complex cytosolic component
nuclear factor of activated T-cells 'c'
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029226.1 RefSeqGene

    Range
    5159..138552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278669.2NP_001265598.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform F

    See identical proteins and their annotated locations for NP_001265598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (F).
    Source sequence(s)
    EU887559, EU887563, U80917
    Consensus CDS
    CCDS62467.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000389377.2, ENST00000427363.6
    Conserved Domains (2) summary
    cd07881
    Location:416590
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:595695
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. NM_001278670.2NP_001265599.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform G

    See identical proteins and their annotated locations for NP_001265599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame exon in the 3' coding region, compared to variant 6. The encoded isoform (G) lacks an internal segment in the C-terminal region, compared to isoform F.
    Source sequence(s)
    EU887561, EU887563, U80917
    Consensus CDS
    CCDS62468.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000442435.1, ENST00000542384.5
    Conserved Domains (2) summary
    cd07881
    Location:416590
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:595695
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. NM_001278672.2NP_001265601.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform H

    See identical proteins and their annotated locations for NP_001265601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate 5' terminal exon, which results in a different 5' UTR and 5' coding region, and lacks an in-frame exon in the 3' coding region, compared to variant 6. The encoded isoform (H) is shorter; it has a distinct N-terminus and lacks an internal segment in the C-terminal region, compared to isoform F.
    Source sequence(s)
    EU887562, EU887563, HY039825
    Consensus CDS
    CCDS62469.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000466489.1, ENST00000586434.1
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  4. NM_001278673.1NP_001265602.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform J

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has an alternate 5' terminal exon and lacks an internal exon in the 5' region, which results in a downstream translation start codon, compared to variant 6. The encoded isoform (J) is shorter at the N-terminus, compared to isoform F.
    Source sequence(s)
    AK293760, EU887559, EU887563, HY039825
    Consensus CDS
    CCDS62471.1
    UniProtKB/Swiss-Prot
    O95644
    UniProtKB/TrEMBL
    B4DER8, F5H4S8
    Related
    ENSP00000439992.1, ENST00000545796.5
    Conserved Domains (2) summary
    cl08275
    Location:1118
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    cl15674
    Location:123223
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  5. NM_001278675.2NP_001265604.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform I

    See identical proteins and their annotated locations for NP_001265604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences, compared to variant 6. These differences result in distinct 5' and 3' UTRs and 5' and 3' terminal coding regions, compared to variant 6. The encoded isoform (I) is shorter and has distinct N- and C-termini, compared to isoform F.
    Source sequence(s)
    AA621079, AC018445, EU887566, HY039825
    Consensus CDS
    CCDS62470.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000467181.1, ENST00000592223.5
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  6. NM_006162.5NP_006153.2  nuclear factor of activated T-cells, cytoplasmic 1 isoform B

    See identical proteins and their annotated locations for NP_006153.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 6. The encoded isoform (B) is truncated at the C-terminus, compared to isoform F.
    Source sequence(s)
    EU887563, U80917
    Consensus CDS
    CCDS12015.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000253506.5, ENST00000253506.9
    Conserved Domains (2) summary
    cd07881
    Location:416590
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:595695
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  7. NM_172387.3NP_765975.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform C

    See identical proteins and their annotated locations for NP_765975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' terminal exon, which results in a different 5' UTR and 5' coding region, compared to variant 6. The encoded isoform (C) is shorter and has a distinct N-terminus, compared to isoform F.
    Source sequence(s)
    EU887560, EU887563, HY039825, U80918
    Consensus CDS
    CCDS32850.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000327850.3, ENST00000329101.8
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  8. NM_172388.3NP_765976.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform D

    See identical proteins and their annotated locations for NP_765976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon in the 5' region, which results in a downstream translation start codon, and has an alternate splice site in the 3' coding region, compared to variant 6. The encoded isoform (D) is shorter at both the N- and C- termini, compared to isoform F.
    Source sequence(s)
    AW014910, EU887563, U80919
    Consensus CDS
    CCDS12016.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000380892.2, ENST00000397790.6
    Conserved Domains (2) summary
    cl08275
    Location:1118
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    cl15674
    Location:123223
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  9. NM_172389.3NP_765977.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform E

    See identical proteins and their annotated locations for NP_765977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' terminal exon, which results in a different 5' UTR and 5' coding region, and uses an alternate splice site in the 3' coding region, compared to variant 6. The encoded isoform (E, also known as C.b) is shorter; it has a distinct N-terminus and is truncated at the C-terminus, compared to isoform F.
    Source sequence(s)
    EU887563, HY039825, U59736
    Consensus CDS
    CCDS59327.1
    UniProtKB/Swiss-Prot
    O95644
    Related
    ENSP00000316553.5, ENST00000318065.9
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  10. NM_172390.3NP_765978.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform A

    See identical proteins and their annotated locations for NP_765978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two exons and its transcription extends past a splice site that is used in variant 6, which results in a novel 3' coding region and 3' UTR, compared to variant 6. The encoded isoform (A) is shorter and has a distinct C-terminus, compared to isoform F.
    Source sequence(s)
    AA621079, AC018445, AK292641, EU887565
    Consensus CDS
    CCDS59326.1
    UniProtKB/Swiss-Prot
    O95644
    UniProtKB/TrEMBL
    A8K9C6
    Related
    ENSP00000466194.1, ENST00000591814.5
    Conserved Domains (3) summary
    cd07881
    Location:416590
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:595695
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl26464
    Location:53292
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    79395930..79529323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025783.2XP_016881272.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1

    Related
    ENSP00000468111.1, ENST00000587635.5
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