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LRRC18 leucine rich repeat containing 18 [ Homo sapiens (human) ]

Gene ID: 474354, updated on 24-Nov-2020

Summary

Official Symbol
LRRC18provided by HGNC
Official Full Name
leucine rich repeat containing 18provided by HGNC
Primary source
HGNC:HGNC:23199
See related
Ensembl:ENSG00000165383 MIM:619002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ933; UNQ9338; VKGE9338
Expression
Biased expression in testis (RPKM 1.7) and lung (RPKM 0.1) See more
Orthologs

Genomic context

See LRRC18 in Genome Data Viewer
Location:
10q11.23
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (48909480..48940126, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50117528..50147980, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene uncharacterized LOC105378299 Neighboring gene uncharacterized LOC105378298 Neighboring gene microRNA 4294

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
GeneReviews: Not available
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC34773

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006939.4NP_001006940.3  leucine-rich repeat-containing protein 18

    See identical proteins and their annotated locations for NP_001006940.3

    Status: VALIDATED

    Source sequence(s)
    AC060234
    Consensus CDS
    CCDS31197.1
    UniProtKB/Swiss-Prot
    Q8N456
    Related
    ENSP00000363275.3, ENST00000374160.7
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
  2. NM_001378102.1NP_001365031.1  leucine-rich repeat-containing protein 18

    Status: VALIDATED

    Source sequence(s)
    AC060234

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    48909480..48940126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539823.1XP_011538125.1  leucine-rich repeat-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_011538125.1

    UniProtKB/Swiss-Prot
    Q8N456
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
  2. XM_011539822.1XP_011538124.1  leucine-rich repeat-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_011538124.1

    UniProtKB/Swiss-Prot
    Q8N456
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
  3. XM_017016276.1XP_016871765.1  leucine-rich repeat-containing protein 18 isoform X1

    UniProtKB/Swiss-Prot
    Q8N456
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
  4. XM_011539826.3XP_011538128.1  leucine-rich repeat-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_011538128.1

    UniProtKB/Swiss-Prot
    Q8N456
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
  5. XM_017016277.2XP_016871766.1  leucine-rich repeat-containing protein 18 isoform X1

    UniProtKB/Swiss-Prot
    Q8N456
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
  6. XM_011539828.2XP_011538130.1  leucine-rich repeat-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_011538130.1

    UniProtKB/Swiss-Prot
    Q8N456
    Conserved Domains (2) summary
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:54108
    LRR_8; Leucine rich repeat
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