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Lrrc18 leucine rich repeat containing 18 [ Mus musculus (house mouse) ]

Gene ID: 67580, updated on 5-Mar-2024

Summary

Official Symbol
Lrrc18provided by MGI
Official Full Name
leucine rich repeat containing 18provided by MGI
Primary source
MGI:MGI:1914830
See related
Ensembl:ENSMUSG00000041673 AllianceGenome:MGI:1914830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTLR1; 4930442L21Rik
Summary
Predicted to be located in cytoplasm. Orthologous to human LRRC18 (leucine rich repeat containing 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 144.2) See more
Orthologs
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Genomic context

See Lrrc18 in Genome Data Viewer
Location:
14 B; 14 19.61 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32713339..32737257)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32991382..33015300)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 4 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36674 Neighboring gene WD repeat and FYVE domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4104 Neighboring gene STARR-positive B cell enhancer ABC_E1893 Neighboring gene STARR-seq mESC enhancer starr_36348 Neighboring gene predicted gene, 25498 Neighboring gene predicted pseudogene 6340

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 18
Names
testis-specific LRR protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146021.1NP_001139493.1  leucine-rich repeat-containing protein 18 isoform 2

    See identical proteins and their annotated locations for NP_001139493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) lacks N-terminal sequence when it is compared to isoform 1.
    Source sequence(s)
    AK005666, AK006063, AK015365, BB017856, BC048444
    Consensus CDS
    CCDS49440.1
    UniProtKB/TrEMBL
    D3Z3F9
    Related
    ENSMUSP00000113608.2, ENSMUST00000120866.8
    Conserved Domains (2) summary
    PLN00113
    Location:49200
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_026253.4NP_080529.1  leucine-rich repeat-containing protein 18 isoform 1

    See identical proteins and their annotated locations for NP_080529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC165262, AK014952, AK015365
    Consensus CDS
    CCDS26924.1
    UniProtKB/Swiss-Prot
    Q6P8T8, Q80ZT3, Q9CQ07, Q9CW01, Q9DA89
    UniProtKB/TrEMBL
    D3Z3F9
    Related
    ENSMUSP00000041199.5, ENSMUST00000038956.12
    Conserved Domains (2) summary
    PLN00113
    Location:49200
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32713339..32737257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519457.4XP_006519520.1  leucine-rich repeat-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_006519520.1

    UniProtKB/Swiss-Prot
    Q6P8T8, Q80ZT3, Q9CQ07, Q9CW01, Q9DA89
    UniProtKB/TrEMBL
    D3Z3F9
    Conserved Domains (2) summary
    PLN00113
    Location:49200
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_006519458.4XP_006519521.1  leucine-rich repeat-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_006519521.1

    UniProtKB/Swiss-Prot
    Q6P8T8, Q80ZT3, Q9CQ07, Q9CW01, Q9DA89
    UniProtKB/TrEMBL
    D3Z3F9
    Conserved Domains (2) summary
    PLN00113
    Location:49200
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:3051
    LRR_RI; leucine-rich repeat [structural motif]