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NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 [ Homo sapiens (human) ]

Gene ID: 4725, updated on 1-Jun-2020

Summary

Official Symbol
NDUFS5provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit S5provided by HGNC
Primary source
HGNC:HGNC:7712
See related
Ensembl:ENSG00000168653 MIM:603847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CI15K; CI-15k
Summary
This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in heart (RPKM 174.0), fat (RPKM 138.7) and 25 other tissues See more
Orthologs

Genomic context

See NDUFS5 in Genome Data Viewer
Location:
1p34.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39026295..39034636)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39491967..39500308)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1 pseudogene 2 Neighboring gene akirin 1 Neighboring gene microtubule actin crosslinking factor 1 Neighboring gene RNA, U6 small nuclear 608, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 44

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex I NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Names
CI-15 kDa
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
NADH:ubiquinone oxidoreductase 15 kDa IP subunit
complex I-15 kDa
NP_001171908.1
NP_004543.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028193.1 RefSeqGene

    Range
    5056..13321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184979.1NP_001171908.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

    See identical proteins and their annotated locations for NP_001171908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI244607, AL606465, BC001884
    Consensus CDS
    CCDS434.1
    UniProtKB/Swiss-Prot
    O43920
    UniProtKB/TrEMBL
    Q6IBA0
    Related
    ENSP00000362058.3, ENST00000372967.3
    Conserved Domains (1) summary
    pfam10200
    Location:196
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
  2. NM_004552.3NP_004543.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

    See identical proteins and their annotated locations for NP_004543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI244607, AL606465, BC093057
    Consensus CDS
    CCDS434.1
    UniProtKB/Swiss-Prot
    O43920
    UniProtKB/TrEMBL
    Q6IBA0
    Related
    ENSP00000362060.3, ENST00000372969.8
    Conserved Domains (1) summary
    pfam10200
    Location:196
    Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    39026295..39034636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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