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NAB1 NGFI-A binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4664, updated on 22-Sep-2022

Summary

Official Symbol
NAB1provided by HGNC
Official Full Name
NGFI-A binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7626
See related
Ensembl:ENSG00000138386 MIM:600800; AllianceGenome:HGNC:7626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 20.8), esophagus (RPKM 13.9) and 25 other tissues See more
Orthologs
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Genomic context

See NAB1 in Genome Data Viewer
Location:
2q32.2
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (190648895..190692766)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (191138204..191182082)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (191513621..191557492)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene U7 small nuclear RNA Neighboring gene NEMP2 divergent transcript Neighboring gene RN7SK pseudogene 179 Neighboring gene uncharacterized LOC124907946 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5899

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in Schwann cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of epidermis development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NGFI-A-binding protein 1
Names
EGR-1-binding protein 1
EGR1 binding protein 1
transcriptional regulatory protein p54

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321312.2NP_001308241.1  NGFI-A-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, AK292446, DB457461
    Consensus CDS
    CCDS2307.1
    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    UniProtKB/TrEMBL
    A8K8T1
    Related
    ENSP00000387089.1, ENST00000409581.5
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  2. NM_001321313.1NP_001308242.1  NGFI-A-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006460
    Consensus CDS
    CCDS2307.1
    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  3. NM_001321314.1NP_001308243.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, U47007
    Consensus CDS
    CCDS82545.1
    UniProtKB/Swiss-Prot
    Q13506
    UniProtKB/TrEMBL
    B8ZZS2
    Related
    ENSP00000386682.1, ENST00000409641.5
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  4. NM_001321315.1NP_001308244.1  NGFI-A-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, AK296549
    UniProtKB/Swiss-Prot
    Q13506
    UniProtKB/TrEMBL
    B4DKG1
    Conserved Domains (3) summary
    pfam04902
    Location:324456
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:174318
    NCD2; NAB conserved region 2 (NCD2)
  5. NM_005966.4NP_005957.2  NGFI-A-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_005957.2

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, BC035724, CF137213, CN288145, U47007
    Consensus CDS
    CCDS2307.1
    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Related
    ENSP00000336894.5, ENST00000337386.10
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    190648895..190692766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444447.1XP_047300403.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  2. XM_005246582.2XP_005246639.1  NGFI-A-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005246639.1

    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  3. XM_047444465.1XP_047300421.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  4. XM_047444446.1XP_047300402.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  5. XM_047444459.1XP_047300415.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  6. XM_047444449.1XP_047300405.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  7. XM_047444464.1XP_047300420.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  8. XM_047444473.1XP_047300429.1  NGFI-A-binding protein 1 isoform X3

  9. XM_047444454.1XP_047300410.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  10. XM_017004174.1XP_016859663.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  11. XM_047444475.1XP_047300431.1  NGFI-A-binding protein 1 isoform X3

  12. XM_047444444.1XP_047300400.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  13. XM_047444450.1XP_047300406.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  14. XM_047444462.1XP_047300418.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  15. XM_047444445.1XP_047300401.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  16. XM_047444458.1XP_047300414.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  17. XM_017004170.2XP_016859659.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  18. XM_047444474.1XP_047300430.1  NGFI-A-binding protein 1 isoform X3

  19. XM_047444456.1XP_047300412.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  20. XM_047444467.1XP_047300423.1  NGFI-A-binding protein 1 isoform X3

  21. XM_047444443.1XP_047300399.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  22. XM_047444457.1XP_047300413.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  23. XM_047444469.1XP_047300425.1  NGFI-A-binding protein 1 isoform X3

  24. XM_047444448.1XP_047300404.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  25. XM_047444461.1XP_047300417.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  26. XM_047444471.1XP_047300427.1  NGFI-A-binding protein 1 isoform X3

  27. XM_047444452.1XP_047300408.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  28. XM_047444476.1XP_047300432.1  NGFI-A-binding protein 1 isoform X3

  29. XM_024452917.2XP_024308685.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  30. XM_017004173.2XP_016859662.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  31. XM_047444472.1XP_047300428.1  NGFI-A-binding protein 1 isoform X3

  32. XM_047444453.1XP_047300409.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  33. XM_005246583.2XP_005246640.1  NGFI-A-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005246640.1

    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  34. XM_047444460.1XP_047300416.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  35. XM_047444470.1XP_047300426.1  NGFI-A-binding protein 1 isoform X3

  36. XM_017004172.3XP_016859661.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  37. XM_017004175.3XP_016859664.1  NGFI-A-binding protein 1 isoform X3

    Conserved Domains (3) summary
    pfam04902
    Location:324456
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:174318
    NCD2; NAB conserved region 2 (NCD2)
  38. XM_017004176.2XP_016859665.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  39. XM_047444466.1XP_047300422.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
  40. XM_047444451.1XP_047300407.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1
  41. XM_047444468.1XP_047300424.1  NGFI-A-binding protein 1 isoform X3

  42. XM_011511219.4XP_011509521.1  NGFI-A-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011509521.1

    UniProtKB/Swiss-Prot
    Q13506, Q9UEV1
    Conserved Domains (3) summary
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:583
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:191317
    NCD2; NAB conserved region 2 (NCD2)
  43. XM_047444442.1XP_047300398.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9UEV1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    191138204..191182082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)