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NAB1 NGFI-A binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4664, updated on 10-Oct-2020

Summary

Official Symbol
NAB1provided by HGNC
Official Full Name
NGFI-A binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7626
See related
Ensembl:ENSG00000138386 MIM:600800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 20.8), esophagus (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See NAB1 in Genome Data Viewer
Location:
2q32.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (190648860..190692766)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (191513621..191557492)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373802 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene uncharacterized LOC105376748 Neighboring gene RN7SK pseudogene 179 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5899 Neighboring gene glutaminase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Schwann cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
myelination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of epidermis development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NGFI-A-binding protein 1
Names
EGR-1-binding protein 1
EGR1 binding protein 1
transcriptional regulatory protein p54

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321312.2NP_001308241.1  NGFI-A-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, AK292446, DB457461
    Consensus CDS
    CCDS2307.1
    UniProtKB/Swiss-Prot
    Q13506
    UniProtKB/TrEMBL
    A8K8T1
    Related
    ENSP00000387089.1, ENST00000409581.5
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  2. NM_001321313.1NP_001308242.1  NGFI-A-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006460
    Consensus CDS
    CCDS2307.1
    UniProtKB/Swiss-Prot
    Q13506
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  3. NM_001321314.1NP_001308243.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, U47007
    Consensus CDS
    CCDS82545.1
    UniProtKB/Swiss-Prot
    Q13506
    UniProtKB/TrEMBL
    B8ZZS2
    Related
    ENSP00000386682.1, ENST00000409641.5
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  4. NM_001321315.1NP_001308244.1  NGFI-A-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, AK296549
    UniProtKB/Swiss-Prot
    Q13506
    UniProtKB/TrEMBL
    B4DKG1
    Conserved Domains (3) summary
    pfam04902
    Location:324456
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:174318
    NCD2; NAB conserved region 2 (NCD2)
  5. NM_005966.4NP_005957.2  NGFI-A-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_005957.2

    Status: VALIDATED

    Source sequence(s)
    AC006460, AF045451, BC035724, CF137213, CN288145, U47007
    Consensus CDS
    CCDS2307.1
    UniProtKB/Swiss-Prot
    Q13506
    Related
    ENSP00000336894.5, ENST00000337386.10
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    190648860..190692766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004170.1XP_016859659.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13506
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  2. XM_017004174.1XP_016859663.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  3. XM_005246582.1XP_005246639.1  NGFI-A-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005246639.1

    UniProtKB/Swiss-Prot
    Q13506
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  4. XM_024452917.1XP_024308685.1  NGFI-A-binding protein 1 isoform X1

    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  5. XM_005246583.1XP_005246640.1  NGFI-A-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005246640.1

    UniProtKB/Swiss-Prot
    Q13506
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  6. XM_017004172.2XP_016859661.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  7. XM_017004175.2XP_016859664.1  NGFI-A-binding protein 1 isoform X3

    Conserved Domains (3) summary
    pfam04902
    Location:324456
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:174318
    NCD2; NAB conserved region 2 (NCD2)
  8. XM_017004173.1XP_016859662.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  9. XM_017004176.1XP_016859665.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13506
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  10. XM_017004171.1XP_016859660.1  NGFI-A-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  11. XM_011511219.3XP_011509521.1  NGFI-A-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011509521.1

    UniProtKB/Swiss-Prot
    Q13506
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322486
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  12. XM_005246586.1XP_005246643.1  NGFI-A-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005246643.1

    UniProtKB/TrEMBL
    B8ZZS2
    Conserved Domains (3) summary
    pfam04905
    Location:190317
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:322485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
  13. XM_005246587.1XP_005246644.1  NGFI-A-binding protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005246644.1

    Conserved Domains (3) summary
    pfam04902
    Location:324456
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:174318
    NCD2; NAB conserved region 2 (NCD2)
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