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Nab1 Ngfi-A binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17936, updated on 12-Feb-2024

Summary

Official Symbol
Nab1provided by MGI
Official Full Name
Ngfi-A binding protein 1provided by MGI
Primary source
MGI:MGI:107564
See related
Ensembl:ENSMUSG00000002881 AllianceGenome:MGI:107564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within several processes, including endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be active in nucleus. Is expressed in genitourinary system; lung epithelium; paraxial mesenchyme; and rhombomere. Orthologous to human NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.5), liver E18 (RPKM 8.4) and 28 other tissues See more
Orthologs
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Genomic context

See Nab1 in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52494146..52539553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52455849..52500712, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00897 Neighboring gene STARR-seq mESC enhancer starr_00898 Neighboring gene predicted gene, 31955 Neighboring gene STARR-seq mESC enhancer starr_00899 Neighboring gene STARR-positive B cell enhancer ABC_E9178 Neighboring gene predicted gene, 23460 Neighboring gene STARR-positive B cell enhancer ABC_E7723 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ribosomal protein S27A, pseudogene 1 Neighboring gene predicted gene 53065

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NGFI-A-binding protein 1
Names
EGR-1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420345.1NP_001407274.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    UniProtKB/Swiss-Prot
    Q61122, Q99J24
    UniProtKB/TrEMBL
    E9PZ64
  2. NM_001420346.1NP_001407275.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    UniProtKB/TrEMBL
    A0A087WSU4, E9PZ64
  3. NM_001420347.1NP_001407276.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    UniProtKB/TrEMBL
    A0A087WSU4, E9PZ64
  4. NM_008667.4NP_032693.2  NGFI-A-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_032693.2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    Consensus CDS
    CCDS14944.1
    UniProtKB/Swiss-Prot
    Q61122, Q99J24
    UniProtKB/TrEMBL
    E9PZ64
    Related
    ENSMUSP00000066696.8, ENSMUST00000069792.14
    Conserved Domains (3) summary
    pfam04905
    Location:189316
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:321485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:683
    NCD1; NAB conserved region 1 (NCD1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52494146..52539553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)