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Nab1 Ngfi-A binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17936, updated on 2-Nov-2024

Summary

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Official Symbol
Nab1provided by MGI
Official Full Name
Ngfi-A binding protein 1provided by MGI
Primary source
MGI:MGI:107564
See related
Ensembl:ENSMUSG00000002881 AllianceGenome:MGI:107564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within several processes, including endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; lung epithelium; and paraxial mesenchyme. Orthologous to human NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 10.5), liver E18 (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nab1 in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52494146..52539553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52455849..52500712, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00897 Neighboring gene STARR-seq mESC enhancer starr_00898 Neighboring gene predicted gene, 31955 Neighboring gene STARR-seq mESC enhancer starr_00899 Neighboring gene STARR-positive B cell enhancer ABC_E9178 Neighboring gene predicted gene, 23460 Neighboring gene STARR-positive B cell enhancer ABC_E7723 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ribosomal protein S27A, pseudogene 1 Neighboring gene predicted gene 53065

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel mutants of NAB corepressors enhance activation by Egr transactivators. Svaren J, et al. EMBO J, 1998 Oct 15. PMID 9774344, Free PMC Article
  2. The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Buitrago M, et al. Nat Med, 2005 Aug. PMID 16025126
  3. Active gene repression by the Egr2.NAB complex during peripheral nerve myelination. Mager GM, et al. J Biol Chem, 2008 Jun 27. PMID 18456662, Free PMC Article
  4. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Russo MW, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624335, Free PMC Article
  5. Nab proteins are essential for peripheral nervous system myelination. Le N, et al. Nat Neurosci, 2005 Jul. PMID 16136673

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter.
    Title: Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.
  2. Egr2 directly represses genes during myelination in conjunction with NAB corepressors
    Title: Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
  3. Nab1 is a potent inhibitor of cardiac growth in response to pathological stimuli in vivo.
    Title: The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
  4. Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
    Title: Nab proteins are essential for peripheral nervous system myelination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within endochondral ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myelination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of epidermis development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NGFI-A-binding protein 1
Names
EGR-1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420345.1 → NP_001407274.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    UniProtKB/Swiss-Prot
    Q61122, Q99J24

  2. NM_001420346.1 → NP_001407275.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    UniProtKB/TrEMBL
    A0A087WSU4

  3. NM_001420347.1 → NP_001407276.1  NGFI-A-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    UniProtKB/TrEMBL
    A0A087WSU4
    Related
    ENSMUSP00000141191.2, ENSMUST00000186764.7

  4. NM_008667.4 → NP_032693.2  NGFI-A-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_032693.2

    Status: VALIDATED

    Source sequence(s)
    AC164428
    Consensus CDS
    CCDS14944.1
    UniProtKB/Swiss-Prot
    Q61122, Q99J24
    UniProtKB/TrEMBL
    E9PZ64
    Related
    ENSMUSP00000066696.8, ENSMUST00000069792.14
    Conserved Domains (3) summary
    pfam04905
    Location:189 → 316
    NCD2; NAB conserved region 2 (NCD2)
    pfam04902
    Location:321 → 485
    Nab1; Conserved region in Nab1
    pfam04904
    Location:6 → 83
    NCD1; NAB conserved region 1 (NCD1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52494146..52539553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61122.2 GenPept UniProtKB/Swiss-Prot:Q61122

Gene LinkOut

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