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MYD88 MYD88 innate immune signal transduction adaptor [ Homo sapiens (human) ]

Gene ID: 4615, updated on 10-Jan-2021

Summary

Official Symbol
MYD88provided by HGNC
Official Full Name
MYD88 innate immune signal transduction adaptorprovided by HGNC
Primary source
HGNC:HGNC:7562
See related
Ensembl:ENSG00000172936 MIM:602170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD68; MYD88D
Summary
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in appendix (RPKM 32.5), bone marrow (RPKM 32.2) and 25 other tissues See more
Orthologs
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Genomic context

See MYD88 in Genome Data Viewer
Location:
3p22.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (38138661..38143022)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38179969..38184513)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene uncharacterized LOC105377033 Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene uncharacterized LOC101928234 Neighboring gene oxidative stress responsive kinase 1 Neighboring gene cell division cycle 42 pseudogene Neighboring gene solute carrier family 22 member 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
TIR domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Toll binding IEA
Inferred from Electronic Annotation
more info
 
Toll-like receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
death receptor binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
JNK cascade IEA
Inferred from Electronic Annotation
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to oxidised low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to protozoan ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
 
induced systemic resistance IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-17 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-23 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
regulation of chemokine (C-X-C motif) ligand 1 production IEA
Inferred from Electronic Annotation
more info
 
regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neutrophil migration IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to molecule of fungal origin IEA
Inferred from Electronic Annotation
more info
 
response to peptidoglycan IEA
Inferred from Electronic Annotation
more info
 
response to virus IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
type I interferon signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myeloid differentiation primary response protein MyD88
Names
mutant myeloid differentiation primary response 88
myeloid differentiation primary response 88
myeloid differentiation primary response gene (88)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016964.1 RefSeqGene

    Range
    5001..9545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_157

mRNA and Protein(s)

  1. NM_001172566.2NP_001166037.2  myeloid differentiation primary response protein MyD88 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK298666, AP006309, BC013589, DA040090
    Consensus CDS
    CCDS54568.1
    Related
    ENSP00000497991.1, ENST00000650112.1
    Conserved Domains (1) summary
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
  2. NM_001172567.2NP_001166038.2  myeloid differentiation primary response protein MyD88 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK296570, AL832906, AP006309
    Consensus CDS
    CCDS54565.1
    Related
    ENSP00000391753.3, ENST00000421516.3
    Conserved Domains (2) summary
    smart00255
    Location:160304
    TIR; Toll - interleukin 1 - resistance
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
  3. NM_001172568.2NP_001166039.2  myeloid differentiation primary response protein MyD88 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK296570, AP006309, BC013589
    Consensus CDS
    CCDS54567.1
    Related
    ENSP00000401399.3, ENST00000417037.7
    Conserved Domains (2) summary
    smart00255
    Location:115251
    TIR; Toll - interleukin 1 - resistance
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
  4. NM_001172569.3NP_001166040.2  myeloid differentiation primary response protein MyD88 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK298666, AP006309, BC013589
    Consensus CDS
    CCDS54566.1
    Related
    ENSP00000499012.1, ENST00000651800.1
    Conserved Domains (1) summary
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
  5. NM_001365876.1NP_001352805.1  myeloid differentiation primary response protein MyD88 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP006309
    Related
    ENSP00000498576.1, ENST00000652213.1
    Conserved Domains (2) summary
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
    cl23749
    Location:160207
    TIR_2; TIR domain
  6. NM_001365877.1NP_001352806.1  myeloid differentiation primary response protein MyD88 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP006309
    Conserved Domains (2) summary
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
    cl23749
    Location:115162
    TIR_2; TIR domain
  7. NM_001374787.1NP_001361716.1  myeloid differentiation primary response protein MyD88 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AP006309
    Conserved Domains (2) summary
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88
    cl23749
    Location:160217
    TIR_2; TIR domain
  8. NM_001374788.1NP_001361717.1  myeloid differentiation primary response protein MyD88 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP006309
    Conserved Domains (1) summary
    smart00255
    Location:4140
    TIR; Toll - interleukin 1 - resistance
  9. NM_002468.5NP_002459.3  myeloid differentiation primary response protein MyD88 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC013589, BP242808, BP339466
    Consensus CDS
    CCDS2674.2
    Related
    ENSP00000498360.1, ENST00000650905.1
    Conserved Domains (2) summary
    smart00255
    Location:160296
    TIR; Toll - interleukin 1 - resistance
    cd08312
    Location:29106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

RNA

  1. NR_164663.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP006309

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    38138661..38143022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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