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MYCL MYCL proto-oncogene, bHLH transcription factor [ Homo sapiens (human) ]

Gene ID: 4610, updated on 21-Dec-2019

Summary

Official Symbol
MYCLprovided by HGNC
Official Full Name
MYCL proto-oncogene, bHLH transcription factorprovided by HGNC
Primary source
HGNC:HGNC:7555
See related
Ensembl:ENSG00000116990 MIM:164850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMYC; L-Myc; MYCL1; bHLHe38
Expression
Broad expression in skin (RPKM 18.4), pancreas (RPKM 11.3) and 17 other tissues See more
Orthologs

Genomic context

See MYCL in Genome Data Viewer
Location:
1p34.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39895428..39901917, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40361096..40367687, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378667 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene Sharpr-MPRA regulatory region 6057 Neighboring gene MYCL antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 2A Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene uncharacterized LOC105378669 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein L-Myc
Names
class E basic helix-loop-helix protein 38
l-myc-1 proto-oncogene
myc-related gene from lung cancer
protein L-Myc-1
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033081.3NP_001028253.1  protein L-Myc isoform 1

    See identical proteins and their annotated locations for NP_001028253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI144219, AL033527
    Consensus CDS
    CCDS30682.1
    UniProtKB/Swiss-Prot
    P12524
    Related
    ENSP00000361903.2, ENST00000372816.3
    Conserved Domains (2) summary
    cd00083
    Location:279333
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:2228
    Myc_N; Myc amino-terminal region
  2. NM_001033082.3NP_001028254.2  protein L-Myc isoform 3

    See identical proteins and their annotated locations for NP_001028254.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' region and uses an alternate, upstream start codon, compared to variant 1. It encodes isoform 3, which is longer than isoform 1.
    Source sequence(s)
    AI144219, AK296078, AL033527
    Consensus CDS
    CCDS53300.1
    UniProtKB/Swiss-Prot
    P12524
    Related
    ENSP00000380494.2, ENST00000397332.2
    Conserved Domains (2) summary
    cd00083
    Location:309363
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:26258
    Myc_N; Myc amino-terminal region
  3. NM_005376.5NP_005367.2  protein L-Myc isoform 2

    See identical proteins and their annotated locations for NP_005367.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1. The resulting isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL033527, BC011864, BX101968
    Consensus CDS
    CCDS44117.2
    UniProtKB/Swiss-Prot
    P12524
    Related
    ENSP00000361902.1, ENST00000372815.1
    Conserved Domains (1) summary
    pfam01056
    Location:26234
    Myc_N; Myc amino-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    39895428..39901917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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