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Mycl v-myc avian myelocytomatosis viral oncogene lung carcinoma derived [ Mus musculus (house mouse) ]

Gene ID: 16918, updated on 18-Sep-2024

Summary

Official Symbol
Myclprovided by MGI
Official Full Name
v-myc avian myelocytomatosis viral oncogene lung carcinoma derivedprovided by MGI
Primary source
MGI:MGI:96799
See related
Ensembl:ENSMUSG00000028654 AllianceGenome:MGI:96799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L-myc; Lmyc1; Mycl1; Lmyc-1; bHLHe38
Summary
This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in whole brain E14.5 (RPKM 22.3), CNS E11.5 (RPKM 19.2) and 19 other tissues See more
Orthologs
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Genomic context

See Mycl in Genome Data Viewer
Location:
4 D2.2; 4 57.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122889414..122896278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122995588..123002490)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3510 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:122616319-122616620 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene STARR-positive B cell enhancer ABC_E7983 Neighboring gene predicted gene, 54255 Neighboring gene STARR-positive B cell enhancer ABC_E11253 Neighboring gene STARR-positive B cell enhancer ABC_E2710 Neighboring gene STARR-positive B cell enhancer ABC_E3511 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4662 Neighboring gene STARR-positive B cell enhancer ABC_E4663 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102165

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein L-Myc
Names
L-myc-1 proto-oncogene protein
lung carcinoma myc related oncogene 1
protein L-Myc-1
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived
v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303121.2NP_001290050.1  protein L-Myc isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606906
    UniProtKB/Swiss-Prot
    P10166
    Conserved Domains (2) summary
    cd00083
    Location:313367
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:26249
    Myc_N; Myc amino-terminal region
  2. NM_001421176.1NP_001408105.1  protein L-Myc isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606906
  3. NM_001421177.1NP_001408106.1  protein L-Myc isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606906
    UniProtKB/Swiss-Prot
    P10166, Q5FWI7
    UniProtKB/TrEMBL
    Q3UIE0
  4. NM_008506.4NP_032532.1  protein L-Myc isoform 1

    See identical proteins and their annotated locations for NP_032532.1

    Status: VALIDATED

    Source sequence(s)
    AL606906
    Consensus CDS
    CCDS18606.1
    UniProtKB/Swiss-Prot
    P10166, Q5FWI7
    UniProtKB/TrEMBL
    Q3UIE0
    Related
    ENSMUSP00000030407.8, ENSMUST00000030407.8
    Conserved Domains (2) summary
    pfam01056
    Location:2219
    Myc_N; Myc amino-terminal region
    cd11457
    Location:280368
    bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    122889414..122896278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)