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Mycl v-myc avian myelocytomatosis viral oncogene lung carcinoma derived [ Mus musculus (house mouse) ]

Gene ID: 16918, updated on 29-Nov-2022

Summary

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Official Symbol
Myclprovided by MGI
Official Full Name
v-myc avian myelocytomatosis viral oncogene lung carcinoma derivedprovided by MGI
Primary source
MGI:MGI:96799
See related
Ensembl:ENSMUSG00000028654 AllianceGenome:MGI:96799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L-myc; Lmyc1; Mycl1; Lmyc-1; bHLHe38
Summary
This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in whole brain E14.5 (RPKM 22.3), CNS E11.5 (RPKM 19.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Mycl in Genome Data Viewer
Location:
4 D2.2; 4 57.36 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122889381..122896283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122995588..123002490)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene predicted gene, 54255 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An Eco RI restriction length polymorphism at the murine L-myc locus. Dolcetti R, et al. Nucleic Acids Res, 1988 Dec 23. PMID 2905449, Free PMC Article
  2. The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells. Anderson DA 3rd, et al. Proc Natl Acad Sci U S A, 2020 Mar 3. PMID 32071205, Free PMC Article
  3. Promotion of direct reprogramming by transformation-deficient Myc. Nakagawa M, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660764, Free PMC Article
  4. Long-depth imaging of specific gene expressions in whole-mount mouse embryos with single-photon excitation confocal fluorescence microscopy and FISH. Palmes-Saloma C, et al. J Struct Biol, 2000 Jul. PMID 10945970
  5. Structure and expression of the murine L-myc gene. Legouy E, et al. EMBO J, 1987 Nov. PMID 2828024, Free PMC Article

See all (94) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
    Title: The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
  2. Deletion of Mycl in two genetically engineered models of SCLC resulted in strong suppression of SCLC
    Title: Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
  3. Mycl1 is expressed exclusively by dendritic cells; unlike c-Myc, the L-Myc transcription factor is not repressed by interferons, and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation
    Title: L-Myc expression by dendritic cells is required for optimal T-cell priming.
  4. We conclude that neither N-Myc nor L-Myc is likely to play important roles in long-term hair cell maintenance
    Title: N-Myc and L-Myc are essential for hair cell formation but not maintenance.
  5. L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc.
    Title: Promotion of direct reprogramming by transformation-deficient Myc.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102165

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein L-Myc
Names
L-myc-1 proto-oncogene protein
lung carcinoma myc related oncogene 1
protein L-Myc-1
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived
v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303121.1 → NP_001290050.1  protein L-Myc isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AL606906, BC053059, CJ164908
    UniProtKB/Swiss-Prot
    P10166
    Conserved Domains (2) summary
    cd00083
    Location:313 → 367
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:26 → 249
    Myc_N; Myc amino-terminal region

  2. NM_008506.3 → NP_032532.1  protein L-Myc isoform 1

    See identical proteins and their annotated locations for NP_032532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC053059, CJ164908
    Consensus CDS
    CCDS18606.1
    UniProtKB/Swiss-Prot
    P10166, Q5FWI7
    UniProtKB/TrEMBL
    Q3UIE0
    Related
    ENSMUSP00000030407.8, ENSMUST00000030407.8
    Conserved Domains (2) summary
    pfam01056
    Location:2 → 219
    Myc_N; Myc amino-terminal region
    cd11457
    Location:280 → 368
    bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    122889381..122896283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502821.4 → XP_006502884.1  protein L-Myc isoform X1

    See identical proteins and their annotated locations for XP_006502884.1

    UniProtKB/Swiss-Prot
    P10166, Q5FWI7
    UniProtKB/TrEMBL
    Q3UIE0
    Conserved Domains (2) summary
    pfam01056
    Location:2 → 219
    Myc_N; Myc amino-terminal region
    cd11457
    Location:280 → 368
    bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10166.1 GenPept UniProtKB/Swiss-Prot:P10166

Gene LinkOut

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