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MYBL1 MYB proto-oncogene like 1 [ Homo sapiens (human) ]

Gene ID: 4603, updated on 21-Dec-2019

Summary

Official Symbol
MYBL1provided by HGNC
Official Full Name
MYB proto-oncogene like 1provided by HGNC
Primary source
HGNC:HGNC:7547
See related
Ensembl:ENSG00000185697 MIM:159405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMYB; A-MYB
Expression
Broad expression in lymph node (RPKM 9.0), testis (RPKM 6.1) and 15 other tissues See more
Orthologs

Genomic context

See MYBL1 in Genome Data Viewer
Location:
8q13.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (66562175..66613218, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67474410..67525484, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene RNA, U6 small nuclear 1324, pseudogene Neighboring gene vexin Neighboring gene uncharacterized LOC105375884 Neighboring gene valosin containing protein interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120059, MGC120061

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
male meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transposition ISS
Inferred from Sequence or Structural Similarity
more info
 
piRNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myb-related protein A
Names
myb-like protein 1
v-myb avian myeloblastosis viral oncogene homolog-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080416.4NP_001073885.1  myb-related protein A isoform 1

    See identical proteins and their annotated locations for NP_001073885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC083928, DR003430, X13294
    Consensus CDS
    CCDS47867.1
    UniProtKB/Swiss-Prot
    P10243
    Related
    ENSP00000429633.2, ENST00000522677.7
    Conserved Domains (4) summary
    smart00717
    Location:87135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242286
    LMSTEN; LMSTEN motif
    pfam09316
    Location:486647
    Cmyb_C; C-myb, C-terminal
  2. NM_001144755.3NP_001138227.1  myb-related protein A isoform 2

    See identical proteins and their annotated locations for NP_001138227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC083928, BC101188, DR003430
    Consensus CDS
    CCDS55241.1
    UniProtKB/Swiss-Prot
    P10243
    Related
    ENSP00000428011.2, ENST00000524176.2
    Conserved Domains (3) summary
    pfam09316
    Location:486647
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3898
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:84270
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
  3. NM_001294282.2NP_001281211.1  myb-related protein A isoform 3

    See identical proteins and their annotated locations for NP_001281211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC083928, BC101186, DR003430
    UniProtKB/TrEMBL
    Q495G0
    Conserved Domains (3) summary
    pfam09316
    Location:485646
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3898
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:84270
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    66562175..66613218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013455.1XP_016868944.1  myb-related protein A isoform X1

  2. XM_017013457.1XP_016868946.1  myb-related protein A isoform X4

  3. XM_011517535.3XP_011515837.1  myb-related protein A isoform X6

    Conserved Domains (4) summary
    smart00717
    Location:87135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242286
    LMSTEN; LMSTEN motif
    pfam09316
    Location:491652
    Cmyb_C; C-myb, C-terminal
  4. XM_011517533.3XP_011515835.1  myb-related protein A isoform X3

    Conserved Domains (4) summary
    smart00717
    Location:87135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242286
    LMSTEN; LMSTEN motif
    pfam09316
    Location:491652
    Cmyb_C; C-myb, C-terminal
  5. XM_017013456.1XP_016868945.1  myb-related protein A isoform X2

  6. XM_017013458.1XP_016868947.1  myb-related protein A isoform X5

  7. XM_017013459.1XP_016868948.1  myb-related protein A isoform X7

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