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Mybl1 myeloblastosis oncogene-like 1 [ Mus musculus (house mouse) ]

Gene ID: 17864, updated on 12-May-2024

Summary

Official Symbol
Mybl1provided by MGI
Official Full Name
myeloblastosis oncogene-like 1provided by MGI
Primary source
MGI:MGI:99925
See related
Ensembl:ENSMUSG00000025912 AllianceGenome:MGI:99925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A-myb; repro9; G1-419-6
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including male gamete generation; negative regulation of transposition; and piRNA biosynthetic process. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human MYBL1 (MYB proto-oncogene like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 1.8), testis adult (RPKM 1.4) and 14 other tissues See more
Orthologs
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Genomic context

See Mybl1 in Genome Data Viewer
Location:
1 A2; 1 2.08 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (9737632..9770664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9667407..9700439, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610203C22 gene Neighboring gene alcohol dehydrogenase, iron containing, 1 Neighboring gene STARR-positive B cell enhancer ABC_E4303 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00166 Neighboring gene vexin Neighboring gene STARR-seq mESC enhancer starr_00167 Neighboring gene VISTA enhancer mm1546 Neighboring gene STARR-seq mESC enhancer starr_00168 Neighboring gene valosin containing protein (p97)/p47 complex interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7714 Neighboring gene RIKEN cDNA 1700034P13 gene Neighboring gene STARR-seq mESC enhancer starr_00169 Neighboring gene predicted gene, 39590 Neighboring gene translation machinery-associated protein 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • MGC123416

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myb-related protein A
Names
myb-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290397.1NP_001277326.1  myb-related protein A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC103620, AC158790
    Consensus CDS
    CCDS69861.1
    UniProtKB/TrEMBL
    E9QLX9, Q3ZB50
    Related
    ENSMUSP00000111128.3, ENSMUST00000115468.9
    Conserved Domains (4) summary
    smart00717
    Location:87135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242285
    LMSTEN; LMSTEN motif
    pfam09316
    Location:485646
    Cmyb_C; C-myb, C-terminal
  2. NM_008651.3NP_032677.2  myb-related protein A isoform 1

    See identical proteins and their annotated locations for NP_032677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC103620, AC158790
    Consensus CDS
    CCDS35510.1
    UniProtKB/TrEMBL
    A0A0R4J132, Q3ZB50
    Related
    ENSMUSP00000086034.5, ENSMUST00000088658.11
    Conserved Domains (4) summary
    smart00717
    Location:87135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242285
    LMSTEN; LMSTEN motif
    pfam09316
    Location:485646
    Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    9737632..9770664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495461.1XP_006495524.1  myb-related protein A isoform X1

    UniProtKB/TrEMBL
    Q3ZB50
    Conserved Domains (3) summary
    PLN03091
    Location:84192
    PLN03091; hypothetical protein; Provisional
    pfam09316
    Location:450609
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3898
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  2. XM_011238350.2XP_011236652.1  myb-related protein A isoform X3

    Conserved Domains (1) summary
    pfam09316
    Location:211370
    Cmyb_C; C-myb, C-terminal
  3. XM_011238349.3XP_011236651.1  myb-related protein A isoform X2

    UniProtKB/TrEMBL
    Q3ZB50
    Conserved Domains (4) summary
    PLN03091
    Location:84192
    PLN03091; hypothetical protein; Provisional
    pfam07988
    Location:242285
    LMSTEN; LMSTEN motif
    pfam09316
    Location:485644
    Cmyb_C; C-myb, C-terminal
    pfam13921
    Location:3898
    Myb_DNA-bind_6; Myb-like DNA-binding domain