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IRS1 insulin receptor substrate 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 459985, updated on 2-Nov-2023

Summary

Official Symbol
IRS1provided by VGNC
Official Full Name
insulin receptor substrate 1provided by VGNC
Primary source
VGNC:VGNC:1981
Locus tag
CK820_G0010956
See related
Ensembl:ENSPTRG00000012989
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
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Genomic context

See IRS1 in Genome Data Viewer
Location:
chromosome: 2B
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_04 current NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (128884325..128951683, complement)

Chromosome 2B - NC_072400.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107973649 Neighboring gene dedicator of cytokinesis 10 Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene rhomboid domain containing 1 Neighboring gene collagen type IV alpha 4 chain

Genomic regions, transcripts, and products

Genomic Sequence:
NC_072400.1 Chromosome 2B Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
insulin receptor substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Genomic

  1. NC_072400.1 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

    Range
    128884325..128951683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003309496.5XP_003309544.1  insulin receptor substrate 1

    See identical proteins and their annotated locations for XP_003309544.1

    UniProtKB/TrEMBL
    A0A2J8NFK7, A0A6D2WIP8, H2QJJ4, K7D5X7
    Conserved Domains (2) summary
    cd01204
    Location:160263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
  2. XM_009444442.4XP_009442717.1  insulin receptor substrate 1

    See identical proteins and their annotated locations for XP_009442717.1

    UniProtKB/TrEMBL
    A0A2J8NFK7, A0A6D2WIP8, H2QJJ4, K7D5X7
    Related
    ENSPTRP00000022194.3
    Conserved Domains (2) summary
    cd01204
    Location:160263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain