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Irs1 insulin receptor substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 16367, updated on 23-Mar-2024

Summary

Official Symbol
Irs1provided by MGI
Official Full Name
insulin receptor substrate 1provided by MGI
Primary source
MGI:MGI:99454
See related
Ensembl:ENSMUSG00000055980 AllianceGenome:MGI:99454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G972R; IRS-1
Summary
Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in cellular response to fatty acid. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (insulin receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 15.6), subcutaneous fat pad adult (RPKM 14.2) and 20 other tissues See more
Orthologs
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Genomic context

See Irs1 in Genome Data Viewer
Location:
1 C5; 1 42.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (82210826..82269160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (82233105..82291439, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53566 Neighboring gene microRNA 6344 Neighboring gene STARR-seq mESC enhancer starr_01474 Neighboring gene STARR-seq mESC enhancer starr_01475 Neighboring gene STARR-seq mESC enhancer starr_01476 Neighboring gene rhomboid domain containing 1 Neighboring gene predicted gene, 46095 Neighboring gene STARR-seq mESC enhancer starr_01477 Neighboring gene collagen, type IV, alpha 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to fatty acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of somatostatin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to caffeine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of insulin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin receptor substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010570.4NP_034700.2  insulin receptor substrate 1

    See identical proteins and their annotated locations for NP_034700.2

    Status: VALIDATED

    Source sequence(s)
    AC123690, AC137845
    Consensus CDS
    CCDS15096.1
    UniProtKB/Swiss-Prot
    P35569
    UniProtKB/TrEMBL
    Q543V3
    Related
    ENSMUSP00000063795.3, ENSMUST00000069799.3
    Conserved Domains (3) summary
    cd01204
    Location:155258
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:17110
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    82210826..82269160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)