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Irs1 insulin receptor substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 16367, updated on 12-Jun-2018
Official Symbol
Irs1provided by MGI
Official Full Name
insulin receptor substrate 1provided by MGI
Primary source
MGI:MGI:99454
See related
Ensembl:ENSMUSG00000055980 Vega:OTTMUSG00000016464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G972R; IRS-1
Expression
Broad expression in ovary adult (RPKM 15.6), subcutaneous fat pad adult (RPKM 14.2) and 20 other tissues See more
Orthologs
See Irs1 in Genome Data Viewer
Location:
1 C5; 1 42.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (82233105..82291439, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (82229680..82288014, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene Neighboring gene microRNA 6344 Neighboring gene rhomboid domain containing 1 Neighboring gene predicted gene, 46095 Neighboring gene collagen, type IV, alpha 4 Neighboring gene collagen, type IV, alpha 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NOT insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of somatostatin secretion ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import in response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to caffeine ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
caveola ISO
Inferred from Sequence Orthology
more info
 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
insulin receptor complex ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
insulin receptor substrate 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010570.4NP_034700.2  insulin receptor substrate 1

    See identical proteins and their annotated locations for NP_034700.2

    Status: VALIDATED

    Source sequence(s)
    AC123690, AC137845
    Consensus CDS
    CCDS15096.1
    UniProtKB/Swiss-Prot
    P35569
    UniProtKB/TrEMBL
    Q543V3
    Related
    ENSMUSP00000063795.2, OTTMUSP00000017705, ENSMUST00000069799.2, OTTMUST00000039671
    Conserved Domains (3) summary
    cd01204
    Location:155258
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:17110
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    82233105..82291439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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