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MVD mevalonate diphosphate decarboxylase [ Homo sapiens (human) ]

Gene ID: 4597, updated on 5-Nov-2017
Official Symbol
MVDprovided by HGNC
Official Full Name
mevalonate diphosphate decarboxylaseprovided by HGNC
Primary source
HGNC:HGNC:7529
See related
Ensembl:ENSG00000167508 MIM:603236; Vega:OTTHUMG00000137865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPD; MDDase; POROK7; FP17780
Summary
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.6), duodenum (RPKM 12.3) and 25 other tissues See more
Orthologs
Location:
16q24.2
Exon count:
13
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (88651935..88663153, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88718343..88729495, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 17C Neighboring gene cytochrome b-245 alpha chain Neighboring gene SNAI3 antisense RNA 1 Neighboring gene snail family transcriptional repressor 3 Neighboring gene ring finger protein 166

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
diphosphomevalonate decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
diphosphomevalonate decarboxylase activity TAS
Traceable Author Statement
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
dolichyl diphosphate biosynthetic process TAS
Traceable Author Statement
more info
 
isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
isoprenoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
NOT peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
diphosphomevalonate decarboxylase
Names
mevalonate (diphospho) decarboxylase
mevalonate pyrophosphate decarboxylase
NP_002452.1
XP_011521388.1
XP_011521389.1
XP_011521390.1
XP_011521391.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052674.1 RefSeqGene

    Range
    5005..16214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002461.2NP_002452.1  diphosphomevalonate decarboxylase

    See identical proteins and their annotated locations for NP_002452.1

    Status: REVIEWED

    Source sequence(s)
    AC116552, BC000011, BI752043, HY026498, U49260
    Consensus CDS
    CCDS10968.1
    UniProtKB/Swiss-Prot
    P53602
    Related
    ENSP00000301012.3, OTTHUMP00000175197, ENST00000301012.7, OTTHUMT00000269547
    Conserved Domains (1) summary
    PLN02407
    Location:10337
    PLN02407; diphosphomevalonate decarboxylase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

    Range
    88651935..88663153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523086.2XP_011521388.1  diphosphomevalonate decarboxylase isoform X1

    Conserved Domains (1) summary
    PLN02407
    Location:10371
    PLN02407; diphosphomevalonate decarboxylase
  2. XM_011523087.2XP_011521389.1  diphosphomevalonate decarboxylase isoform X2

    Conserved Domains (1) summary
    PLN02407
    Location:4350
    PLN02407; diphosphomevalonate decarboxylase
  3. XM_011523088.2XP_011521390.1  diphosphomevalonate decarboxylase isoform X3

    Conserved Domains (1) summary
    PLN02407
    Location:4316
    PLN02407; diphosphomevalonate decarboxylase
  4. XM_011523089.2XP_011521391.1  diphosphomevalonate decarboxylase isoform X4

    Conserved Domains (2) summary
    PLN02407
    Location:19220
    PLN02407; diphosphomevalonate decarboxylase
    pfam00408
    Location:65129
    PGM_PMM_IV; Phosphoglucomutase/phosphomannomutase, C-terminal domain

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    90129698..90140909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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