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EPAS1 endothelial PAS domain protein 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 459204, updated on 2-Nov-2023

Summary

Official Symbol
EPAS1provided by VGNC
Official Full Name
endothelial PAS domain protein 1provided by VGNC
Primary source
VGNC:VGNC:244
Locus tag
CK820_G0028031
See related
Ensembl:ENSPTRG00000011891
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
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Genomic context

See EPAS1 in Genome Data Viewer
Location:
chromosome: 2A
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_04 current NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2A NC_072399.1 (46441855..46531179)

Chromosome 2A - NC_072399.1Genomic Context describing neighboring genes Neighboring gene S1 RNA binding domain 1 Neighboring gene protein kinase C epsilon Neighboring gene uncharacterized LOC104004964 Neighboring gene transmembrane protein 247

Genomic regions, transcripts, and products

Genomic Sequence:
NC_072399.1 Chromosome 2A Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
endothelial PAS domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Genomic

  1. NC_072399.1 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

    Range
    46441855..46531179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001147219.6XP_001147219.1  endothelial PAS domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_001147219.1

    UniProtKB/TrEMBL
    A0A2I3TA92, A0A2J8LL81, A0A6D2VU71, H2QHV1
    Related
    ENSPTRP00000020413.4
    Conserved Domains (5) summary
    smart00091
    Location:86147
    PAS; PAS domain
    cd00083
    Location:1268
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08778
    Location:833869
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam08447
    Location:254341
    PAS_3; PAS fold
    pfam11413
    Location:518549
    HIF-1; Hypoxia-inducible factor-1
  2. XM_054677824.1XP_054533799.1  endothelial PAS domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3TA92