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CLCN6 chloride voltage-gated channel 6 [ Pan troglodytes (chimpanzee) ]

Gene ID: 457955, updated on 17-Aug-2024

Summary

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Official Symbol
CLCN6provided by VGNC
Official Full Name
chloride voltage-gated channel 6provided by VGNC
Primary source
VGNC:VGNC:10576
Locus tag
CK820_G0034955
See related
Ensembl:ENSPTRG00000000154
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (220150340..220187129, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (11112004..11148960)

Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene natriuretic peptide B Neighboring gene natriuretic peptide A Neighboring gene methylenetetrahydrofolate reductase Neighboring gene chromosome 1 C1orf167 homolog Neighboring gene splicing factor 3B subunit 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
chloride transport protein 6; H(+)/Cl(-) exchange transporter 6
Names
chloride channel 6
chloride channel protein 6
chloride channel, voltage-sensitive 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    220150340..220187129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063786177.1 → XP_063642247.1  H(+)/Cl(-) exchange transporter 6 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RZ30, A0A2I3TUH4

  2. XM_001140805.6 → XP_001140805.3  H(+)/Cl(-) exchange transporter 6 isoform X2

    UniProtKB/TrEMBL
    A0A2J8KXB5, A0A8I3B2N9, K7ACC4, K7CM04, K7DRB2
    Conserved Domains (2) summary
    cd03685
    Location:49 → 588
    ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
    cd04591
    Location:600 → 856
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  3. XM_063786172.1 → XP_063642242.1  H(+)/Cl(-) exchange transporter 6 isoform X1

    UniProtKB/TrEMBL
    K7CM04

  4. XM_009448326.5 → XP_009446601.3  H(+)/Cl(-) exchange transporter 6 isoform X7

    UniProtKB/TrEMBL
    A0A2I3RKM6
    Conserved Domains (3) summary
    smart00116
    Location:476 → 523
    CBS; Domain in cystathionine beta-synthase and other proteins
    cd04591
    Location:569 → 721
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    cl02915
    Location:20 → 456
    Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...

  5. XM_063786182.1 → XP_063642252.1  H(+)/Cl(-) exchange transporter 6 isoform X6

    UniProtKB/TrEMBL
    A0A2I3RKM6

  6. XM_063786179.1 → XP_063642249.1  H(+)/Cl(-) exchange transporter 6 isoform X4

    UniProtKB/TrEMBL
    K7CM04

  7. XM_063786181.1 → XP_063642251.1  H(+)/Cl(-) exchange transporter 6 isoform X5

    UniProtKB/TrEMBL
    K7CM04

RNA

  1. XR_679837.5 RNA Sequence

  2. XR_010148217.1 RNA Sequence

  3. XR_010148218.1 RNA Sequence

Nucleotide Protein
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