Conserved Protein Domain Family
CBS_pair_EriC_assoc_euk_bac

?
cd04591: CBS_pair_EriC_assoc_euk_bac (this model, PSSM-Id:239964 is obsolete and has been replaced by 341367)
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of chloride ions across biological membranes. CIC-type chloride channels come from all kingdoms of life, have several gene families, and can be gated by voltage. The members of the CIC-type chloride channel are double-barreled: two proteins forming homodimers at a broad interface formed by four helices from each protein. The two pores are not found at this interface, but are completely contained within each subunit, as deduced from the mutational analyses, unlike many other channels, in which four or five identical or structurally related subunits jointly form one pore. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide range of different proteins. CBS domains usually come in tandem repeats, which associate to form a so-called Bateman domain or a CBS pair which is reflected in this model. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain in CLC chloride channel family members have been associated with classic Bartter syndrome, Osteopetrosis, Dent's disease, idiopathic generalized epilepsy, and myotonia.
Statistics
?
PSSM-Id: 239964
Aligned: 74 rows
Threshold Bit Score: 60.7289
Threshold Setting Gi: 71745106
Created: 6-Sep-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_425575     670 APLSVLTQDSMTVEDVETLIKetdyNGFPVVVskd---------seRLIGFAQr-------RELILAIKNarqrqdgvvs 733  chicken
AAF13163      669 LRRYSRRGSLAANGAHMSSGNal-mTDRNISGntl--------lpqSPLHEDQgdr--splAPLLYAQTNqhepivhsla 737  nematode
CAG06383      686 ERTTEIPTGPHDNSGIALKNLfc-sSPDPEGLesptap---elrrpSKRVRISvv----ddGDVEDDMTIreiaeweemq 757  Tetraodon nig...
NP_731635     948 NEVGVNGSPTRTKCKIKPENVlg-ySIEDVDEttnp------eslaESIQKPKsvr---lpRERVIDMSPedqkqwelee 1017 fruit fly
XP_974480     778 EAIFRKSAQLQDVENNDSSPVln-sAGGSMDNkvq--------iipMSPSTSKkvq---lpKERVCDMSPedqriweeeq 845  red flour beetle
EAA07584      702 SAFDIIFRKSATLQDVTPDPEig-sIGTPSIVgse--------vapLTPGISKkvq---lpRERVIDMSPedqkawemee 769  Anopheles gam...
AAB88807      706 TRNLGESPTGSAESAGIALRSlf-cGSPPPEAasekles-cekrklKRVRISLas-----dADLEGEMSPeeileweeqq 778  human
CAK05174      663 GPVPPPKPSEPSTNHTSPDKGps-qSFRRLLRnlfss-----sserHTEGQPQep----ypPPLTDTMTPeqikaweese 732  zebrafish
NP_001022061  677 RSQLQRYVDSQIGTKARFAEAtr-rIKQRLEDees---------erKRREESKsddtedslETTGAGERRasryewedmm 746  nematode
CAI16141      375 RVRVEHFMNHSITTLAKDMPLee-vVKVVTSTdvakyplvestesqILVGIVRr-------AQLVQALKAeppswapgh- 445  human
AAF13163      669 LRRYSRRGSLAANGAHMSSGNal-mTDRNISGntl--------lpqSPLHEDQgdr--splAPLLYAQTNqhepivhsla 737  nematode
CAG06383      686 ERTTEIPTGPHDNSGIALKNLfc-sSPDPEGLesptap---elrrpSKRVRISvv----ddGDVEDDMTIreiaeweemq 757  Tetraodon nig...
NP_731635     948 NEVGVNGSPTRTKCKIKPENVlg-ySIEDVDEttnp------eslaESIQKPKsvr---lpRERVIDMSPedqkqwelee 1017 fruit fly
XP_974480     778 EAIFRKSAQLQDVENNDSSPVln-sAGGSMDNkvq--------iipMSPSTSKkvq---lpKERVCDMSPedqriweeeq 845  red flour beetle
EAA07584      702 SAFDIIFRKSATLQDVTPDPEig-sIGTPSIVgse--------vapLTPGISKkvq---lpRERVIDMSPedqkawemee 769  Anopheles gam...
AAB88807      706 TRNLGESPTGSAESAGIALRSlf-cGSPPPEAasekles-cekrklKRVRISLas-----dADLEGEMSPeeileweeqq 778  human
CAK05174      663 GPVPPPKPSEPSTNHTSPDKGps-qSFRRLLRnlfss-----sserHTEGQPQep----ypPPLTDTMTPeqikaweese 732  zebrafish
NP_001022061  677 RSQLQRYVDSQIGTKARFAEAtr-rIKQRLEDees---------erKRREESKsddtedslETTGAGERRasryewedmm 746  nematode
CAI16141      375 RVRVEHFMNHSITTLAKDMPLee-vVKVVTSTdvakyplvestesqILVGIVRr-------AQLVQALKAeppswapgh- 445  human
XP_425575     734 nsivyftedppelppnsphplklrrILNLSPFTV--TDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRH 808  chicken
AAF13163      738 kra----------eilskkldmeevAIDPAPFQL--VRGTSLYKVHTLFSLLALNHAYVTEKGRLCGVVAVKELREA 802  nematode
CAG06383      758 ---------------ldeqvnfnncKIDPAPFQL--VERTSLHKTHTIFSLLGLDHAYVTSIGRLIGVVSLKELRKA 817  Tetraodon nigrov...
NP_731635    1018 m-------------lkpidlqkanvHIDPSPFQL--VERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKA 1079 fruit fly
XP_974480     846 ---------------mqlpvdftscHIDPAPFQL--VEKTSLLKVHSLFSMVGVNHAYVTAIGKLVGVVGLKDLRKA 905  red flour beetle
EAA07584      770 ---------------makpidvgnlHIDPAPFQL--VERTSILKVHSLFSMVGINHAYVTNVGRLVGVVALKELRTA 829  Anopheles gambia...
AAB88807      779 ---------------ldepvnfsdcKIDPAPFQL--VERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKA 838  human
CAK05174      733 ---------------mdkpleinqiRIDPSPFQL--VERTSLHKTHTLFSLLGLSHAYVTNTGKLVGVVALKELQKA 792  zebrafish
NP_001022061  747 ---------------lnqkldlsqlDIDSTPFQL--SEYTSLFKAHSLFSLLGLNRAYVTKKGQLIGVVALKEVCFL 806  nematode
CAI16141      446 ----------------qclqdilaaGCPTEPVTLklSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKA 506  human
AAF13163      738 kra----------eilskkldmeevAIDPAPFQL--VRGTSLYKVHTLFSLLALNHAYVTEKGRLCGVVAVKELREA 802  nematode
CAG06383      758 ---------------ldeqvnfnncKIDPAPFQL--VERTSLHKTHTIFSLLGLDHAYVTSIGRLIGVVSLKELRKA 817  Tetraodon nigrov...
NP_731635    1018 m-------------lkpidlqkanvHIDPSPFQL--VERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKA 1079 fruit fly
XP_974480     846 ---------------mqlpvdftscHIDPAPFQL--VEKTSLLKVHSLFSMVGVNHAYVTAIGKLVGVVGLKDLRKA 905  red flour beetle
EAA07584      770 ---------------makpidvgnlHIDPAPFQL--VERTSILKVHSLFSMVGINHAYVTNVGRLVGVVALKELRTA 829  Anopheles gambia...
AAB88807      779 ---------------ldepvnfsdcKIDPAPFQL--VERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKA 838  human
CAK05174      733 ---------------mdkpleinqiRIDPSPFQL--VERTSLHKTHTLFSLLGLSHAYVTNTGKLVGVVALKELQKA 792  zebrafish
NP_001022061  747 ---------------lnqkldlsqlDIDSTPFQL--SEYTSLFKAHSLFSLLGLNRAYVTKKGQLIGVVALKEVCFL 806  nematode
CAI16141      446 ----------------qclqdilaaGCPTEPVTLklSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKA 506  human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap