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MYO1F myosin IF [ Homo sapiens (human) ]

Gene ID: 4542, updated on 13-Feb-2019

Summary

Official Symbol
MYO1Fprovided by HGNC
Official Full Name
myosin IFprovided by HGNC
Primary source
HGNC:HGNC:7600
See related
Ensembl:ENSG00000142347 MIM:601480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
Expression
Biased expression in bone marrow (RPKM 41.2), spleen (RPKM 33.9) and 13 other tissues See more
Orthologs

Genomic context

See MYO1F in Genome Data Viewer
Location:
19p13.2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (8520790..8577447, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8585674..8642331, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene zinc finger protein 414 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 10 Neighboring gene long intergenic non-protein coding RNA 1862

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of myosin IF (MYO1F) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
unconventional myosin complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-If
Names
myosin-ID
myosin-Ie

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052844.1 RefSeqGene

    Range
    5001..61658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348355.1NP_001335284.1  unconventional myosin-If isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC092298, AC092316, AC130469
    Conserved Domains (4) summary
    cd11827
    Location:10411093
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    cd01378
    Location:31673
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:713911
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    cl26464
    Location:9541039
    Atrophin-1; Atrophin-1 family
  2. NM_012335.3NP_036467.2  unconventional myosin-If isoform 1

    See identical proteins and their annotated locations for NP_036467.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB210037, BC028071, DA380582
    Consensus CDS
    CCDS42494.1
    UniProtKB/Swiss-Prot
    O00160
    UniProtKB/TrEMBL
    Q4LE34
    Related
    ENSP00000344871.6, ENST00000338257.12
    Conserved Domains (4) summary
    cd11827
    Location:10451097
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    cd01378
    Location:31677
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:717915
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    cl26464
    Location:9581043
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    8520790..8577447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528025.2XP_011526327.1  unconventional myosin-If isoform X2

    Conserved Domains (4) summary
    cd11827
    Location:10621114
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    smart00242
    Location:12707
    MYSc; Myosin. Large ATPases
    cd01378
    Location:31694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:734914
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_011528026.2XP_011526328.1  unconventional myosin-If isoform X3

    Conserved Domains (4) summary
    cd11827
    Location:10371089
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    smart00242
    Location:12682
    MYSc; Myosin. Large ATPases
    cd01378
    Location:31669
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:709889
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. XM_011528027.2XP_011526329.1  unconventional myosin-If isoform X4

    Conserved Domains (4) summary
    cd11827
    Location:10211073
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    smart00242
    Location:12666
    MYSc; Myosin. Large ATPases
    cl22853
    Location:31653
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:693873
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  4. XM_011528024.2XP_011526326.1  unconventional myosin-If isoform X1

    Conserved Domains (4) summary
    cd11827
    Location:10661118
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    smart00242
    Location:12711
    MYSc; Myosin. Large ATPases
    cd01378
    Location:31698
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:738918
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  5. XM_024451522.1XP_024307290.1  unconventional myosin-If isoform X5

    Conserved Domains (4) summary
    cd11827
    Location:660712
    SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
    pfam06017
    Location:332530
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    cl22853
    Location:20292
    Motor_domain; Myosin and Kinesin motor domain
    cl26464
    Location:573658
    Atrophin-1; Atrophin-1 family
  6. XM_011528028.3XP_011526330.1  unconventional myosin-If isoform X6

    Conserved Domains (2) summary
    smart00242
    Location:12508
    MYSc; Myosin. Large ATPases
    cl22853
    Location:31508
    Motor_domain; Myosin and Kinesin motor domain

RNA

  1. XR_001753692.2 RNA Sequence

  2. XR_936180.3 RNA Sequence

  3. XR_936181.2 RNA Sequence

  4. XR_936182.3 RNA Sequence

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