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MT-ND3 mitochondrially encoded NADH dehydrogenase 3 [ Homo sapiens (human) ]

Gene ID: 4537, updated on 13-May-2022

Summary

Official Symbol
MT-ND3provided by HGNC
Official Full Name
mitochondrially encoded NADH dehydrogenase 3provided by HGNC
Primary source
HGNC:HGNC:7458
See related
MIM:516002; AllianceGenome:HGNC:7458
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTND3; ND3
Summary
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone. Part of mitochondrial respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Leigh disease; and Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MT-ND3 in Genome Data Viewer
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (10059..10404)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (10059..10404)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F0 subunit 6 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly Neighboring gene tRNA-Arg Neighboring gene NADH dehydrogenase subunit 4L Neighboring gene NADH dehydrogenase subunit 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADH dehydrogenase (ubiquinone) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex I IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mitochondrial respiratory chain complex I NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NADH dehydrogenase subunit 3
YP_003024033.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    10059..10404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024033.1 NADH dehydrogenase subunit 3 (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024033.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03897
    UniProtKB/TrEMBL
    Q7GXZ5
    Related
    ENSP00000355206.2
    Conserved Domains (1) summary
    MTH00106
    Location:1115
    ND3; NADH dehydrogenase subunit 3; Provisional