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Genet Mol Res. 2015 Dec 21;14(4):17426-31. doi: 10.4238/2015.December.21.12.

Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer.

Author information

1
Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
2
College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
3
Department of Endocrinology, Ningbo Fourth Hospital, Xiangshan, China.
4
School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, China.
5
Department of Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, China.
6
Department of Clinical Pharmacy, The Affiliated Wenling Hospital of Wenzhou Medial University, Wenling, China.

Abstract

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case-control studies to determine the association between the G10398A mutation and breast cancer. We further used the Phylotree to determine the haplogroups of this mutation. The frequencies of this mutation in 500 unrelated healthy controls were also screened. We found that this mutation is very common in the human population, and may be a polymorph.

PMID:
26782384
DOI:
10.4238/2015.December.21.12
[Indexed for MEDLINE]
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