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MT1X metallothionein 1X [ Homo sapiens (human) ]

Gene ID: 4501, updated on 1-Jun-2020

Summary

Official Symbol
MT1Xprovided by HGNC
Official Full Name
metallothionein 1Xprovided by HGNC
Primary source
HGNC:HGNC:7405
See related
Ensembl:ENSG00000187193 MIM:156359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1; MT-1l
Expression
Broad expression in liver (RPKM 301.6), kidney (RPKM 245.8) and 16 other tissues See more
Orthologs

Genomic context

See MT1X in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (56682470..56684196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56716382..56718108)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene metallothionein 1H Neighboring gene metallothionein 1I, pseudogene Neighboring gene developmental pluripotency associated 2 pseudogene 4 Neighboring gene uncharacterized LOC105371286 Neighboring gene uncharacterized LOC105371287

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of metallothionein 1X (MT1X) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to erythropoietin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
response to metal ion TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
metallothionein-1X
Names
MT-1X
MT-IX
metallothionein-IX
testicular tissue protein Li 124

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005952.4NP_005943.1  metallothionein-1X

    See identical proteins and their annotated locations for NP_005943.1

    Status: VALIDATED

    Source sequence(s)
    BC032338, CD101947
    Consensus CDS
    CCDS10768.1
    UniProtKB/Swiss-Prot
    P80297
    UniProtKB/TrEMBL
    A0A140VJP8
    Related
    ENSP00000377995.4, ENST00000394485.5
    Conserved Domains (1) summary
    pfam00131
    Location:161
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    56682470..56684196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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