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MT1M metallothionein 1M [ Homo sapiens (human) ]

Gene ID: 4499, updated on 2-Mar-2021

Summary

Official Symbol
MT1Mprovided by HGNC
Official Full Name
metallothionein 1Mprovided by HGNC
Primary source
HGNC:HGNC:14296
See related
Ensembl:ENSG00000205364 MIM:156357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1; MT1K; MT-1M; MT-IM
Summary
This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
Expression
Broad expression in colon (RPKM 54.9), small intestine (RPKM 40.3) and 14 other tissues See more
Orthologs
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Genomic context

See MT1M in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (56632659..56633981)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56666571..56667893)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene metallothionein 1L, pseudogene Neighboring gene metallothionein 1E Neighboring gene metallothionein 1J, pseudogene Neighboring gene metallothionein 1A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40498, MGC118949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to zinc ion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
metallothionein-1M
Names
metallothionein 1K
metallothionein 1Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030326.1 RefSeqGene

    Range
    5001..6365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176870.3NP_789846.2  metallothionein-1M

    Status: REVIEWED

    Source sequence(s)
    AC026461
    Consensus CDS
    CCDS42166.1
    Related
    ENSP00000369146.3, ENST00000379818.4
    Conserved Domains (1) summary
    pfam00131
    Location:161
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    56632659..56633981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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