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MSRA methionine sulfoxide reductase A [ Homo sapiens (human) ]

Gene ID: 4482, updated on 7-Jun-2020

Summary

Official Symbol
MSRAprovided by HGNC
Official Full Name
methionine sulfoxide reductase Aprovided by HGNC
Primary source
HGNC:HGNC:7377
See related
Ensembl:ENSG00000175806 MIM:601250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMSR
Summary
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Broad expression in kidney (RPKM 12.0), bone marrow (RPKM 3.1) and 21 other tissues See more
Orthologs

Genomic context

See MSRA in Genome Data Viewer
Location:
8p23.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (10054224..10428891)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (9911830..10286401)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 124-1 Neighboring gene uncharacterized LOC105379234 Neighboring gene transmembrane protein 126A pseudogene Neighboring gene uncharacterized LOC112268021 Neighboring gene uncharacterized LINCR-0001 Neighboring gene RNA, U6 small nuclear 729, pseudogene Neighboring gene serine protease 52, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study for quantitative traits in schizophrenia in China.
NHGRI GWA Catalog
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.
NHGRI GWA Catalog
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
NHGRI GWA Catalog
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Genome-wide association study of blood pressure and hypertension.
NHGRI GWA Catalog
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of methionine sulfoxide reductase A (MSRA) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-methionine-(S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide-methionine (S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide-methionine (S)-S-oxide reductase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine metabolic process TAS
Traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein repair TAS
Traceable Author Statement
more info
 
response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial peptide methionine sulfoxide reductase
Names
cytosolic methionine-S-sulfoxide reductase
peptide Met(O) reductase
peptide met (O) reductase
peptide-methionine (S)-S-oxide reductase
NP_001129142.1
NP_001129143.1
NP_001186658.1
NP_036463.1
XP_011542124.1
XP_011542125.1
XP_016868937.1
XP_016868938.1
XP_016868939.1
XP_016868940.1
XP_024302930.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135670.3NP_001129142.1  mitochondrial peptide methionine sulfoxide reductase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC023385, AC034111, AC112673
    Consensus CDS
    CCDS47798.1
    UniProtKB/Swiss-Prot
    Q9UJ68
    Related
    ENSP00000410912.2, ENST00000441698.6
    Conserved Domains (1) summary
    cl00366
    Location:30192
    PMSR; Peptide methionine sulfoxide reductase
  2. NM_001135671.3NP_001129143.1  mitochondrial peptide methionine sulfoxide reductase isoform c

    See identical proteins and their annotated locations for NP_001129143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC023385, AC079200, AC112673
    Consensus CDS
    CCDS47799.1
    UniProtKB/Swiss-Prot
    Q9UJ68
    Related
    ENSP00000371930.5, ENST00000382490.9
    Conserved Domains (1) summary
    PRK00058
    Location:1189
    PRK00058; methionine sulfoxide reductase A; Provisional
  3. NM_001199729.3NP_001186658.1  mitochondrial peptide methionine sulfoxide reductase isoform d

    See identical proteins and their annotated locations for NP_001186658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC023385, AC079200, AC112673
    Consensus CDS
    CCDS56522.1
    UniProtKB/Swiss-Prot
    Q9UJ68
    Related
    ENSP00000436839.1, ENST00000528246.5
    Conserved Domains (1) summary
    PRK00058
    Location:2166
    PRK00058; methionine sulfoxide reductase A; Provisional
  4. NM_012331.5NP_036463.1  mitochondrial peptide methionine sulfoxide reductase isoform a precursor

    See identical proteins and their annotated locations for NP_036463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC023385, AC034111, AC079200, AC112673
    Consensus CDS
    CCDS5975.1
    UniProtKB/Swiss-Prot
    Q9UJ68
    Related
    ENSP00000313921.4, ENST00000317173.9
    Conserved Domains (1) summary
    PRK00058
    Location:30232
    PRK00058; methionine sulfoxide reductase A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    10054224..10428891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013448.2XP_016868937.1  mitochondrial peptide methionine sulfoxide reductase isoform X3

  2. XM_011543822.2XP_011542124.1  mitochondrial peptide methionine sulfoxide reductase isoform X1

    Conserved Domains (1) summary
    cl00366
    Location:30182
    PMSR; Peptide methionine sulfoxide reductase
  3. XM_011543823.2XP_011542125.1  mitochondrial peptide methionine sulfoxide reductase isoform X2

    Conserved Domains (1) summary
    cl00366
    Location:30181
    PMSR; Peptide methionine sulfoxide reductase
  4. XM_024447162.1XP_024302930.1  mitochondrial peptide methionine sulfoxide reductase isoform X6

    Conserved Domains (1) summary
    cl00366
    Location:30110
    PMSR; Peptide methionine sulfoxide reductase
  5. XM_017013451.2XP_016868940.1  mitochondrial peptide methionine sulfoxide reductase isoform X5

  6. XM_017013449.2XP_016868938.1  mitochondrial peptide methionine sulfoxide reductase isoform X4

    UniProtKB/Swiss-Prot
    Q9UJ68
    Conserved Domains (1) summary
    PRK00058
    Location:2166
    PRK00058; methionine sulfoxide reductase A; Provisional
  7. XM_017013450.2XP_016868939.1  mitochondrial peptide methionine sulfoxide reductase isoform X4

    UniProtKB/Swiss-Prot
    Q9UJ68
    Conserved Domains (1) summary
    PRK00058
    Location:2166
    PRK00058; methionine sulfoxide reductase A; Provisional

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    2918137..3294116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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