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ncaldb neurocalcin delta b [ Danio rerio (zebrafish) ]

Gene ID: 445319, updated on 18-Sep-2024

Summary

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Official Symbol
ncaldbprovided by ZNC
Official Full Name
neurocalcin delta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040808-37
See related
Ensembl:ENSDARG00000011334 AllianceGenome:ZFIN:ZDB-GENE-040808-37
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ncald; zgc:100982
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within regulation of axon extension involved in axon guidance. Is expressed in eye. Orthologous to human NCALD (neurocalcin delta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 19
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (12297247..12324526, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (12375915..12405011, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108180138 Neighboring gene grainyhead-like transcription factor 2b Neighboring gene proteasome (prosome, macropain) assembly chaperone 2 Neighboring gene protein tyrosine phosphatase non-receptor type 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. Riessland M, et al. Am J Hum Genet, 2017 Feb 2. PMID 28132687, Free PMC Article
  2. IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Amanda S, et al. Nat Commun, 2022 May 3. PMID 35504924, Free PMC Article
  3. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article
  4. Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Vihtelic TS, et al. Mol Vis, 2005 Dec 13. PMID 16379021
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
neurocalcin-delta B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003776.1 → NP_001003776.1  neurocalcin-delta B

    See identical proteins and their annotated locations for NP_001003776.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079490
    UniProtKB/Swiss-Prot
    Q6AXL4
    Related
    ENSDARP00000019433.4, ENSDART00000016128.7
    Conserved Domains (3) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:100 → 174
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:36 → 89
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    12297247..12324526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159585.4 → XP_005159642.1  neurocalcin-delta B isoform X1

    See identical proteins and their annotated locations for XP_005159642.1

    UniProtKB/Swiss-Prot
    Q6AXL4
    Related
    ENSDARP00000109673.3, ENSDART00000122192.5
    Conserved Domains (3) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:100 → 174
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:36 → 89
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_009294100.4 → XP_009292375.1  neurocalcin-delta B isoform X1

    See identical proteins and their annotated locations for XP_009292375.1

    UniProtKB/Swiss-Prot
    Q6AXL4
    Conserved Domains (3) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:100 → 174
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:36 → 89
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_005159586.5 → XP_005159643.1  neurocalcin-delta B isoform X1

    See identical proteins and their annotated locations for XP_005159643.1

    UniProtKB/Swiss-Prot
    Q6AXL4
    Related
    ENSDARP00000125961.1, ENSDART00000151158.2
    Conserved Domains (3) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:100 → 174
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:36 → 89
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXL4.1 GenPept UniProtKB/Swiss-Prot:Q6AXL4

Gene LinkOut

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