Format

Send to:

Choose Destination

ASNS asparagine synthetase (glutamine-hydrolyzing) [ Homo sapiens (human) ]

Gene ID: 440, updated on 13-Mar-2020

Summary

Official Symbol
ASNSprovided by HGNC
Official Full Name
asparagine synthetase (glutamine-hydrolyzing)provided by HGNC
Primary source
HGNC:HGNC:753
See related
Ensembl:ENSG00000070669 MIM:108370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TS11; ASNSD
Summary
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in brain (RPKM 19.6), testis (RPKM 14.4) and 24 other tissues See more
Orthologs

Genomic context

See ASNS in Genome Data Viewer
Location:
7q21.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (97851677..97928441, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97481429..97501854, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 104 Neighboring gene tachykinin precursor 1 Neighboring gene CZ1P-ASNS readthrough Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 9 Neighboring gene RPS3A pseudogene 29 Neighboring gene olfactory receptor family 7 subfamily E member 7 pseudogene Neighboring gene microRNA 5692a-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
asparagine synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparagine synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
cofactor binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-asparagine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
PERK-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
asparagine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparagine biosynthetic process IC
Inferred by Curator
more info
PubMed 
asparagine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular amino acid biosynthetic process TAS
Traceable Author Statement
more info
 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
response to amino acid IEA
Inferred from Electronic Annotation
more info
 
response to follicle-stimulating hormone IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to methotrexate IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
asparagine synthetase [glutamine-hydrolyzing]
Names
TS11 cell cycle control protein
glutamine-dependent asparagine synthetase
NP_001171546.1
NP_001171547.1
NP_001171548.1
NP_001339425.1
NP_001664.3
NP_597680.2
NP_899199.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033870.2 RefSeqGene

    Range
    61021..81446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178075.2NP_001171546.1  asparagine synthetase [glutamine-hydrolyzing] isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA948141, AC005326, AK302189, BC014621
    Consensus CDS
    CCDS55132.1
    UniProtKB/Swiss-Prot
    P08243
    Related
    ENSP00000406994.1, ENST00000444334.5
    Conserved Domains (3) summary
    PRK09431
    Location:2534
    asnB; asparagine synthetase B; Provisional
    cd00712
    Location:1185
    AsnB; Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a ...
    pfam00733
    Location:214511
    Asn_synthase; Asparagine synthase
  2. NM_001178076.2NP_001171547.1  asparagine synthetase [glutamine-hydrolyzing] isoform c

    See identical proteins and their annotated locations for NP_001171547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 5 and 6 encode the same isoform (c).
    Source sequence(s)
    AA948141, AC005326, BC014621, DA160359
    Consensus CDS
    CCDS55131.1
    UniProtKB/Swiss-Prot
    P08243
    Related
    ENSP00000408472.1, ENST00000455086.5
    Conserved Domains (2) summary
    pfam00733
    Location:152449
    Asn_synthase; Asparagine synthase
    cl00319
    Location:8123
    Gn_AT_II; Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to ...
  3. NM_001178077.1NP_001171548.1  asparagine synthetase [glutamine-hydrolyzing] isoform c

    See identical proteins and their annotated locations for NP_001171548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 5 and 6 encode the same isoform (c).
    Source sequence(s)
    AA948141, BC014621, DB483248
    Consensus CDS
    CCDS55131.1
    UniProtKB/Swiss-Prot
    P08243
    Related
    ENSP00000414379.1, ENST00000437628.5
    Conserved Domains (2) summary
    pfam00733
    Location:152449
    Asn_synthase; Asparagine synthase
    cl00319
    Location:8123
    Gn_AT_II; Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to ...
  4. NM_001352496.2NP_001339425.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AC005326, DN993965
    Consensus CDS
    CCDS5652.1
    Conserved Domains (1) summary
    cl28298
    Location:1555
    GlmS; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis]
  5. NM_001673.5NP_001664.3  asparagine synthetase [glutamine-hydrolyzing] isoform a

    See identical proteins and their annotated locations for NP_001664.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AA948141, AC005326, BC014621
    Consensus CDS
    CCDS5652.1
    UniProtKB/Swiss-Prot
    P08243
    Related
    ENSP00000377845.3, ENST00000394308.8
    Conserved Domains (1) summary
    cl28298
    Location:1555
    GlmS; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis]
  6. NM_133436.3NP_597680.2  asparagine synthetase [glutamine-hydrolyzing] isoform a

    See identical proteins and their annotated locations for NP_597680.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest variant. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AA948141, BC014621, DA961373
    Consensus CDS
    CCDS5652.1
    UniProtKB/Swiss-Prot
    P08243
    Related
    ENSP00000377846.3, ENST00000394309.7
    Conserved Domains (1) summary
    cl28298
    Location:1555
    GlmS; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis]
  7. NM_183356.3NP_899199.2  asparagine synthetase [glutamine-hydrolyzing] isoform a

    See identical proteins and their annotated locations for NP_899199.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AA948141, BC014621, DA160359, DC297828
    Consensus CDS
    CCDS5652.1
    UniProtKB/Swiss-Prot
    P08243
    Related
    ENSP00000175506.4, ENST00000175506.8
    Conserved Domains (1) summary
    cl28298
    Location:1555
    GlmS; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    97851677..97928441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center