U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Asns asparagine synthetase [ Mus musculus (house mouse) ]

Gene ID: 27053, updated on 4-Nov-2022

Summary

Official Symbol
Asnsprovided by MGI
Official Full Name
asparagine synthetaseprovided by MGI
Primary source
MGI:MGI:1350929
See related
Ensembl:ENSMUSG00000029752 AllianceGenome:MGI:1350929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Predicted to be involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and positive regulation of mitotic cell cycle. Predicted to act upstream of or within cellular amino acid biosynthetic process and glutamine metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 65.1), liver E14.5 (RPKM 53.0) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Asns in Genome Data Viewer
Location:
6; 6 A1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (7675165..7693209, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (7675165..7693209, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tachykinin 1 Neighboring gene predicted gene, 35051 Neighboring gene SET pseudogene Neighboring gene RIKEN cDNA 1700012J15 gene Neighboring gene predicted gene, 35194

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables asparagine synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables asparagine synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
asparagine synthetase [glutamine-hydrolyzing]
Names
glutamine-dependent asparagine synthetase
NP_036185.1
XP_006505155.1
XP_006505156.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410605.1NP_001397534.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q8BPC8
  2. NM_001410606.1NP_001397535.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q8BPC8
  3. NM_001410607.1NP_001397536.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q8BPC8
  4. NM_001410608.1NP_001397537.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q8BPC8
  5. NM_001410609.1NP_001397538.1  asparagine synthetase [glutamine-hydrolyzing] isoform b

    Status: VALIDATED

    Source sequence(s)
    AC129291
  6. NM_012055.5NP_036185.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    See identical proteins and their annotated locations for NP_036185.1

    Status: VALIDATED

    Source sequence(s)
    AC129291
    Consensus CDS
    CCDS19907.1
    UniProtKB/Swiss-Prot
    Q61024, Q8BPC8
    Related
    ENSMUSP00000031766.6, ENSMUST00000031766.12
    Conserved Domains (1) summary
    PRK09431
    Location:1560
    asnB; asparagine synthetase B; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    7675165..7693209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505093.4XP_006505156.1  asparagine synthetase [glutamine-hydrolyzing] isoform X1

    UniProtKB/Swiss-Prot
    Q61024
    Conserved Domains (1) summary
    PRK09431
    Location:1560
    asnB; asparagine synthetase B; Provisional
  2. XM_006505092.5XP_006505155.1  asparagine synthetase [glutamine-hydrolyzing] isoform X1

    UniProtKB/Swiss-Prot
    Q61024
    Related
    ENSMUSP00000111204.2, ENSMUST00000115542.8
    Conserved Domains (1) summary
    PRK09431
    Location:1560
    asnB; asparagine synthetase B; Provisional