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Asns asparagine synthetase [ Mus musculus (house mouse) ]

Gene ID: 27053, updated on 2-Nov-2024

Summary

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Official Symbol
Asnsprovided by MGI
Official Full Name
asparagine synthetaseprovided by MGI
Primary source
MGI:MGI:1350929
See related
Ensembl:ENSMUSG00000029752 AllianceGenome:MGI:1350929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Predicted to be involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and positive regulation of mitotic cell cycle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 65.1), liver E14.5 (RPKM 53.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Asns in Genome Data Viewer
Location:
6 A1; 6 3.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (7675169..7693209, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (7675165..7693209, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tachykinin 1 Neighboring gene predicted gene, 35051 Neighboring gene SET pseudogene Neighboring gene STARR-seq mESC enhancer starr_15097 Neighboring gene STARR-seq mESC enhancer starr_15099 Neighboring gene STARR-seq mESC enhancer starr_15100 Neighboring gene STARR-seq mESC enhancer starr_15101 Neighboring gene STARR-seq mESC enhancer starr_15102 Neighboring gene RIKEN cDNA 1700012J15 gene Neighboring gene predicted gene, 35194

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. Clerici S, et al. EMBO Mol Med, 2024 Jun. PMID 38684863, Free PMC Article
  2. Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. Zhu Y, et al. Circulation, 2024 Jun 4. PMID 38586957,
  3. Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver. Iida S, et al. Biol Pharm Bull, 2013. PMID 24292060
  4. Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression. Grima-Reyes M, et al. Sci Adv, 2022 Jul 8. PMID 35857457, Free PMC Article
  5. Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Ruzzo EK, et al. Neuron, 2013 Oct 16. PMID 24139043, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.
    Title: Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.
  2. Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.
    Title: Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.
  3. Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
    Title: Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
  4. Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
    Title: Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
  5. Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.
    Title: Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.
  6. Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.
    Title: Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.
  7. Asns is involved in the regulation of plasma glucose levels.
    Title: Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables asparagine synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-asparagine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in asparagine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within asparagine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in asparagine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to aldosterone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amino acid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to follicle-stimulating hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to light stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
asparagine synthetase [glutamine-hydrolyzing]
Names
glutamine-dependent asparagine synthetase
NP_001397534.1
NP_001397535.1
NP_001397536.1
NP_001397537.1
NP_001397538.1
NP_036185.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410605.1 → NP_001397534.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q3TJA1, Q61024, Q8BPC8

  2. NM_001410606.1 → NP_001397535.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q3TJA1, Q61024, Q8BPC8
    Related
    ENSMUSP00000111204.2, ENSMUST00000115542.8

  3. NM_001410607.1 → NP_001397536.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q3TJA1, Q61024, Q8BPC8

  4. NM_001410608.1 → NP_001397537.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    Status: VALIDATED

    Source sequence(s)
    AC129291
    UniProtKB/Swiss-Prot
    Q3TJA1, Q61024, Q8BPC8

  5. NM_001410609.1 → NP_001397538.1  asparagine synthetase [glutamine-hydrolyzing] isoform b

    Status: VALIDATED

    Source sequence(s)
    AC129291

  6. NM_012055.5 → NP_036185.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

    See identical proteins and their annotated locations for NP_036185.1

    Status: VALIDATED

    Source sequence(s)
    AC129291
    Consensus CDS
    CCDS19907.1
    UniProtKB/Swiss-Prot
    Q3TJA1, Q61024, Q8BPC8
    UniProtKB/TrEMBL
    Q3TV20
    Related
    ENSMUSP00000031766.6, ENSMUST00000031766.12
    Conserved Domains (1) summary
    PRK09431
    Location:1 → 560
    asnB; asparagine synthetase B; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    7675169..7693209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61024.3 GenPept UniProtKB/Swiss-Prot:Q61024

Gene LinkOut

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