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GET3 guided entry of tail-anchored proteins factor 3, ATPase [ Homo sapiens (human) ]

Gene ID: 439, updated on 4-Feb-2024

Summary

Official Symbol
GET3provided by HGNC
Official Full Name
guided entry of tail-anchored proteins factor 3, ATPaseprovided by HGNC
Primary source
HGNC:HGNC:752
See related
Ensembl:ENSG00000198356 MIM:601913; AllianceGenome:HGNC:752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARSA1; ASNA1; CMD2H; TRC40; ARSA-I; ASNA-I
Summary
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in kidney (RPKM 39.3), thyroid (RPKM 34.9) and 25 other tissues See more
Orthologs
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Genomic context

See GET3 in Genome Data Viewer
Location:
19p13.13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12737106..12748323)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12861599..12872815)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12847920..12859137)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12832661-12833279 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12833280-12833897 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12833898-12834516 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12834517-12835133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12842300-12842847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10161 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated TRIR regulatory element Neighboring gene telomerase RNA component interacting RNase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12855878-12856378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10166 Neighboring gene bestrophin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12876343-12876888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12881756-12882256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12882257-12882757 Neighboring gene hook microtubule tethering protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12885288-12885968 Neighboring gene CRISPRi-FlowFISH-validated DNASE2 and PRDX2 regulatory element Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14077 Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 2 Neighboring gene CRISPRi-FlowFISH-validated JUNB and PRDX2 regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated JUNB and PRDX2 regulatory element 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14078 Neighboring gene microRNA 5684

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of arsA arsenite transporter, ATP-binding, homolog 1 (ASNA1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC3821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arsenite transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables membrane insertase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of GET complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of GET complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of GET complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATPase GET3
Names
arsA arsenite transporter, ATP-binding, homolog 1
golgi to ER traffic 3 homolog
transmembrane domain recognition complex 40 kDa ATPase subunit
NP_001358417.1
NP_001358418.1
NP_004308.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051267.1 RefSeqGene

    Range
    5039..15865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001371488.1NP_001358417.1  ATPase GET3

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC018761
    Consensus CDS
    CCDS32920.1
    UniProtKB/Swiss-Prot
    A6NHP8, A8K740, O43681, Q53FC6, Q92849
    UniProtKB/TrEMBL
    B4DEE5
    Conserved Domains (1) summary
    pfam02374
    Location:37340
    ArsA_ATPase; Anion-transporting ATPase
  2. NM_001371489.1NP_001358418.1  ATPase GET3

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC018761
    Consensus CDS
    CCDS32920.1
    UniProtKB/Swiss-Prot
    A6NHP8, A8K740, O43681, Q53FC6, Q92849
    UniProtKB/TrEMBL
    B4DEE5
    Related
    ENSP00000466379.1, ENST00000591090.5
    Conserved Domains (1) summary
    pfam02374
    Location:37340
    ArsA_ATPase; Anion-transporting ATPase
  3. NM_004317.4NP_004308.2  ATPase GET3

    See identical proteins and their annotated locations for NP_004308.2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC002651, BM718941
    Consensus CDS
    CCDS32920.1
    UniProtKB/Swiss-Prot
    A6NHP8, A8K740, O43681, Q53FC6, Q92849
    UniProtKB/TrEMBL
    B4DEE5
    Related
    ENSP00000349887.3, ENST00000357332.8
    Conserved Domains (1) summary
    pfam02374
    Location:37340
    ArsA_ATPase; Anion-transporting ATPase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12737106..12748323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12861599..12872815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)