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MPP3 membrane palmitoylated protein 3 [ Homo sapiens (human) ]

Gene ID: 4356, updated on 7-Jun-2020

Summary

Official Symbol
MPP3provided by HGNC
Official Full Name
membrane palmitoylated protein 3provided by HGNC
Primary source
HGNC:HGNC:7221
See related
Ensembl:ENSG00000161647 MIM:601114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLG3
Summary
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 3.1), lung (RPKM 2.5) and 23 other tissues See more
Orthologs

Genomic context

See MPP3 in Genome Data Viewer
Location:
17q21.31
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43800799..43833194, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41878167..41910547, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 3 Neighboring gene Sharpr-MPRA regulatory region 13819 Neighboring gene CFAP97 domain containing 1 Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene CD300 molecule like family member g

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
MAGUK p55 subfamily member 3
Names
discs, large homolog 3
membrane protein palmitoylated 3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330233.1NP_001317162.1  MAGUK p55 subfamily member 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC003098, U37707
    Consensus CDS
    CCDS82135.1
    UniProtKB/Swiss-Prot
    Q13368
    UniProtKB/TrEMBL
    D3DX46
    Related
    ENSP00000381430.1, ENST00000398393.5
  2. NM_001353080.1NP_001340009.1  MAGUK p55 subfamily member 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC003098
    Conserved Domains (4) summary
    smart00569
    Location:81129
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12039
    Location:238299
    SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
    smart00072
    Location:403579
    GuKc; Guanylate kinase homologues
    cd00992
    Location:143223
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001932.6NP_001923.2  MAGUK p55 subfamily member 3 isoform 1

    See identical proteins and their annotated locations for NP_001923.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    BC056865, DA585178, DB357996, U37707
    Consensus CDS
    CCDS42344.1
    UniProtKB/Swiss-Prot
    Q13368
    Related
    ENSP00000381425.4, ENST00000398389.8
    Conserved Domains (6) summary
    smart00569
    Location:1264
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12039
    Location:230291
    SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
    smart00072
    Location:395571
    GuKc; Guanylate kinase homologues
    cd00992
    Location:135215
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:384572
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:69119
    L27; L27 domain

RNA

  1. NR_003562.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AC003098, BC047017, DB357996, U37707
  2. NR_148342.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC003098
  3. NR_148343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC003098
  4. NR_148344.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC003098
  5. NR_148345.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC003098

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43800799..43833194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721915.2XP_006721978.1  MAGUK p55 subfamily member 3 isoform X1

    See identical proteins and their annotated locations for XP_006721978.1

    UniProtKB/Swiss-Prot
    Q13368
    Conserved Domains (6) summary
    smart00569
    Location:1264
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12039
    Location:230291
    SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
    smart00072
    Location:395571
    GuKc; Guanylate kinase homologues
    cd00992
    Location:135215
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:384572
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:69119
    L27; L27 domain
  2. XM_017024657.2XP_016880146.1  MAGUK p55 subfamily member 3 isoform X5

  3. XM_017024656.1XP_016880145.1  MAGUK p55 subfamily member 3 isoform X4

    Conserved Domains (3) summary
    cd12039
    Location:2889
    SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
    smart00072
    Location:193369
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:182370
    Guanylate_kin; Guanylate kinase
  4. XM_006721916.3XP_006721979.1  MAGUK p55 subfamily member 3 isoform X2

    Conserved Domains (3) summary
    smart00569
    Location:3789
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd00992
    Location:160235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:94144
    L27; L27 domain
  5. XM_017024658.1XP_016880147.1  MAGUK p55 subfamily member 3 isoform X6

    Related
    ENSP00000465486.1, ENST00000496503.5
  6. XM_017024659.1XP_016880148.1  MAGUK p55 subfamily member 3 isoform X7

    Conserved Domains (4) summary
    smart00569
    Location:3789
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12039
    Location:255316
    SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
    cd00992
    Location:160240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:94144
    L27; L27 domain
  7. XM_017024655.1XP_016880144.1  MAGUK p55 subfamily member 3 isoform X3

  8. XM_017024660.1XP_016880149.1  MAGUK p55 subfamily member 3 isoform X8

RNA

  1. XR_001752517.2 RNA Sequence

  2. XR_002958011.1 RNA Sequence

  3. XR_001752512.2 RNA Sequence

  4. XR_001752516.1 RNA Sequence

  5. XR_934466.2 RNA Sequence

  6. XR_001752515.1 RNA Sequence

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