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CD200 CD200 molecule [ Homo sapiens (human) ]

Gene ID: 4345, updated on 21-Dec-2019

Summary

Official Symbol
CD200provided by HGNC
Official Full Name
CD200 moleculeprovided by HGNC
Primary source
HGNC:HGNC:7203
See related
Ensembl:ENSG00000091972 MIM:155970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRC; MOX1; MOX2; OX-2
Summary
This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression
Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues See more
Orthologs

Genomic context

See CD200 in Genome Data Viewer
Location:
3q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (112332573..112362812)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112051194..112081659)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member C1 Neighboring gene chromosome 1 open reading frame 106 pseudogene Neighboring gene ubiquitination factor E4A (UFD2 homolog, yeast) pseudogene Neighboring gene uncharacterized LOC105374042 Neighboring gene uncharacterized LOC105374041 Neighboring gene 3q13.2-q13.31 proximal HERV-H recombination region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycosylated region protein binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
heterotypic cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of leukocyte activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of matrix metallopeptidase secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of arginase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein-glutamine gamma-glutamyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transforming growth factor beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
OX-2 membrane glycoprotein
Names
CD200 antigen
antigen identified by monoclonal antibody MRC OX-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004196.3NP_001004196.2  OX-2 membrane glycoprotein isoform b

    See identical proteins and their annotated locations for NP_001004196.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, that results in an isoform (b) with a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AC112487, AK297194, AL832529, DA773259
    Consensus CDS
    CCDS33818.1
    UniProtKB/Swiss-Prot
    P41217
    Related
    ENSP00000420298.1, ENST00000473539.5
    Conserved Domains (2) summary
    cd05846
    Location:69165
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:181253
    Ig; Immunoglobulin domain
  2. NM_001318826.1NP_001305755.1  OX-2 membrane glycoprotein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon resulting in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AC112487, AK312563, AL832529, DA773259
    Conserved Domains (1) summary
    cl11960
    Location:43112
    Ig; Immunoglobulin domain
  3. NM_001318828.1NP_001305757.1  OX-2 membrane glycoprotein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC112487, AK293399, AL832529, BC022522, DA773259
    Consensus CDS
    CCDS82819.1
    UniProtKB/Swiss-Prot
    P41217
    UniProtKB/TrEMBL
    B4DDZ6, F8W7G1
    Related
    ENSP00000373179.3, ENST00000383681.7
    Conserved Domains (1) summary
    cl11960
    Location:164
    Ig; Immunoglobulin domain
  4. NM_001318830.1NP_001305759.1  OX-2 membrane glycoprotein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in a shorter isoform (c) with a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AK129797, AL832529, DA773259
    Conserved Domains (1) summary
    cl11960
    Location:43112
    Ig; Immunoglobulin domain
  5. NM_001365851.2NP_001352780.1  OX-2 membrane glycoprotein isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC112487
    Conserved Domains (2) summary
    cd05846
    Location:44138
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains
    cl11960
    Location:159228
    Ig; Immunoglobulin domain
  6. NM_001365852.1NP_001352781.1  OX-2 membrane glycoprotein isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC112487
    Conserved Domains (2) summary
    cd05846
    Location:37131
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains
    cl11960
    Location:152221
    Ig; Immunoglobulin domain
  7. NM_001365853.1NP_001352782.1  OX-2 membrane glycoprotein isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC112487
    Conserved Domains (2) summary
    cd05846
    Location:37131
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains
    cl11960
    Location:152221
    Ig; Immunoglobulin domain
  8. NM_001365854.1NP_001352783.1  OX-2 membrane glycoprotein isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC112487
    Conserved Domains (2) summary
    cd05846
    Location:37131
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains
    cl11960
    Location:152221
    Ig; Immunoglobulin domain
  9. NM_001365855.1NP_001352784.1  OX-2 membrane glycoprotein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112487
    Conserved Domains (1) summary
    cl11960
    Location:43112
    Ig; Immunoglobulin domain
  10. NM_005944.7NP_005935.4  OX-2 membrane glycoprotein isoform a precursor

    See identical proteins and their annotated locations for NP_005935.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL832529, BC022522, DA544134
    Consensus CDS
    CCDS2965.1
    UniProtKB/Swiss-Prot
    P41217
    Related
    ENSP00000312766.8, ENST00000315711.12
    Conserved Domains (2) summary
    cd05846
    Location:44140
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    cl11960
    Location:156228
    Ig; Immunoglobulin domain

RNA

  1. NR_158642.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112487
    Related
    ENST00000478595.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    112332573..112362812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004197.1: Suppressed sequence

    Description
    NM_001004197.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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