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MOS MOS proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 4342, updated on 23-Nov-2021

Summary

Official Symbol
MOSprovided by HGNC
Official Full Name
MOS proto-oncogene, serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:7199
See related
Ensembl:ENSG00000172680 MIM:190060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSV
Summary
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
Orthologs
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Genomic context

See MOS in Genome Data Viewer
Location:
8q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (56112942..56113982, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (57025501..57026541, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene competing endogenous lncRNA 3 for miR-645 Neighboring gene nucleophosmin 1 pseudogene 21 Neighboring gene PLAG1 zinc finger Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of v-mos Moloney murine sarcoma viral oncogene homolog (MOS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119962, MGC119963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of meiotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proto-oncogene serine/threonine-protein kinase mos
Names
c-mos
oncogene MOS, Moloney murine sarcoma virus
oocyte maturation factor mos
proto-oncogene c-Mos
v-mos Moloney murine sarcoma viral oncogene homolog
NP_005363.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005372.1NP_005363.1  proto-oncogene serine/threonine-protein kinase mos

    See identical proteins and their annotated locations for NP_005363.1

    Status: VALIDATED

    Source sequence(s)
    AC107376
    Consensus CDS
    CCDS6164.1
    UniProtKB/Swiss-Prot
    P00540
    Related
    ENSP00000310722.1, ENST00000311923.1
    Conserved Domains (1) summary
    cd13979
    Location:56338
    STKc_Mos; Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    56112942..56113982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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