U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnaaf5 dynein, axonemal assembly factor 5 [ Mus musculus (house mouse) ]

Gene ID: 433956, updated on 5-Mar-2024

Summary

Official Symbol
Dnaaf5provided by MGI
Official Full Name
dynein, axonemal assembly factor 5provided by MGI
Primary source
MGI:MGI:3616079
See related
Ensembl:ENSMUSG00000025857 AllianceGenome:MGI:3616079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Heatr2
Summary
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium movement; inner dynein arm assembly; and outer dynein arm assembly. Predicted to act upstream of or within cell projection organization. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 18. Orthologous to human DNAAF5 (dynein axonemal assembly factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.8), ovary adult (RPKM 20.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dnaaf5 in Genome Data Viewer
Location:
5 G2; 5 78.02 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139135888..139172265)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139150133..139186510)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38726 Neighboring gene RIKEN cDNA 6330403L08 gene Neighboring gene STARR-seq mESC enhancer starr_14679 Neighboring gene platelet derived growth factor, alpha Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene STARR-positive B cell enhancer ABC_E1695 Neighboring gene STARR-seq mESC enhancer starr_14685 Neighboring gene STARR-positive B cell enhancer ABC_E10360 Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene golgi to ER traffic protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC60818

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
 
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
NOT located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein axonemal assembly factor 5
Names
HEAT repeat-containing protein 2
dynein assembly factor 5, axonemal

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081265.2NP_001074734.1  dynein axonemal assembly factor 5 isoform 1

    See identical proteins and their annotated locations for NP_001074734.1

    Status: VALIDATED

    Source sequence(s)
    AC125065
    Consensus CDS
    CCDS39349.1
    UniProtKB/Swiss-Prot
    B9EJR8
    Related
    ENSMUSP00000026975.7, ENSMUST00000026975.11
    Conserved Domains (2) summary
    pfam13830
    Location:41198
    DUF4192; Domain of unknown function (DUF4192)
    sd00044
    Location:165193
    HEAT; HEAT repeat [structural motif]
  2. NM_001363485.1NP_001350414.1  dynein axonemal assembly factor 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC158066, BG228650, CK627764
    Consensus CDS
    CCDS90005.1
    UniProtKB/TrEMBL
    B2RY24
    Related
    ENSMUSP00000142924.2, ENSMUST00000196441.2
    Conserved Domains (1) summary
    sd00044
    Location:405433
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139135888..139172265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955669.1 RNA Sequence