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Hdac1 histone deacetylase 1 [ Mus musculus (house mouse) ]

Gene ID: 433759, updated on 5-Jan-2023

Summary

Official Symbol
Hdac1provided by MGI
Official Full Name
histone deacetylase 1provided by MGI
Primary source
MGI:MGI:108086
See related
Ensembl:ENSMUSG00000028800 AllianceGenome:MGI:108086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HD1; RPD3; MommeD5; Hdac1-ps
Summary
Enables several functions, including E-box binding activity; Krueppel-associated box domain binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in heterochromatin; neuronal cell body; and nucleus. Part of NuRD complex and transcription repressor complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 54.8), placenta adult (RPKM 51.1) and 28 other tissues See more
Orthologs
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Genomic context

See Hdac1 in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129409897..129436439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129516104..129542646, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 229, member A Neighboring gene testis-specific serine kinase 3 Neighboring gene MARCKS-like 1 Neighboring gene lymphocyte protein tyrosine kinase Neighboring gene microRNA 8119 Neighboring gene family with sequence similarity 167, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102534, MGC118085

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Krueppel-associated box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase activity TAS
Traceable Author Statement
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone decrotonylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone decrotonylase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin organization TAS
Traceable Author Statement
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endoderm development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in eyelid development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fungiform papilla formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hair follicle placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4 deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of histone deacetylase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription repressor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
histone deacetylase 1
Names
protein deacetylase HDAC1
protein decrotonylase HDAC1
NP_032254.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008228.3NP_032254.1  histone deacetylase 1

    See identical proteins and their annotated locations for NP_032254.1

    Status: VALIDATED

    Source sequence(s)
    AL606921
    Consensus CDS
    CCDS18696.1
    UniProtKB/Swiss-Prot
    O09106, P97476
    UniProtKB/TrEMBL
    A0A8C6G7P8, Q58E49
    Related
    ENSMUSP00000099657.5, ENSMUST00000102597.5
    Conserved Domains (1) summary
    cd10010
    Location:4374
    HDAC1; Histone deacetylase 1 (HDAC1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129409897..129436439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)