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MOBP myelin associated oligodendrocyte basic protein [ Homo sapiens (human) ]

Gene ID: 4336, updated on 10-Oct-2023

Summary

Official Symbol
MOBPprovided by HGNC
Official Full Name
myelin associated oligodendrocyte basic proteinprovided by HGNC
Primary source
HGNC:HGNC:7189
See related
Ensembl:ENSG00000168314 MIM:600948; AllianceGenome:HGNC:7189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable actin binding activity and myosin binding activity. Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion. Predicted to be active in cortical actin cytoskeleton. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward brain (RPKM 31.3) See more
Orthologs
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Genomic context

See MOBP in Genome Data Viewer
Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (39467680..39529497)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (39480633..39542424)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39509171..39570988)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986075 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14229 Neighboring gene ribosomal protein SA Neighboring gene NANOG hESC enhancer GRCh37_chr3:39508789-39509471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:39513805-39514612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:39514613-39515420 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:39547383-39547882 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:39618867-39619806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:39624719-39625251 Neighboring gene NFE2L2 motif-containing MPRA enhancer 66 Neighboring gene NFU1 iron-sulfur cluster scaffold pseudogene 1 Neighboring gene MPRA-validated peak4615 silencer Neighboring gene uncharacterized LOC105377039

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
EBI GWAS Catalog
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RPSA

Clone Names

  • FLJ37799, MGC87379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in central nervous system myelin formation IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myelin-associated oligodendrocyte basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278322.2NP_001265251.1  myelin-associated oligodendrocyte basic protein isoform a

    See identical proteins and their annotated locations for NP_001265251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC092058, AK127034, DA343382
    Consensus CDS
    CCDS63598.1
    UniProtKB/Swiss-Prot
    Q13875
    Related
    ENSP00000312293.6, ENST00000311042.10
    Conserved Domains (1) summary
    cl22851
    Location:168
    PHD_SF; PHD finger superfamily
  2. NM_001278323.2NP_001265252.1  myelin-associated oligodendrocyte basic protein isoform b

    See identical proteins and their annotated locations for NP_001265252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BF511176, DA217942
    Consensus CDS
    CCDS2688.1
    UniProtKB/Swiss-Prot
    A8K2C2, G5E945, Q13874, Q13875, Q6DHZ6, Q8TBJ1
    Related
    ENSP00000506926.1, ENST00000682069.1
    Conserved Domains (2) summary
    PRK06995
    Location:70163
    flhF; flagellar biosynthesis protein FlhF
    cl22851
    Location:169
    PHD_SF; PHD finger superfamily
  3. NM_001393704.1NP_001380633.1  myelin-associated oligodendrocyte basic protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC092058
    Consensus CDS
    CCDS2688.1
    UniProtKB/Swiss-Prot
    A8K2C2, G5E945, Q13874, Q13875, Q6DHZ6, Q8TBJ1
    Related
    ENSP00000508923.1, ENST00000684792.1
    Conserved Domains (2) summary
    PRK06995
    Location:70163
    flhF; flagellar biosynthesis protein FlhF
    cl22851
    Location:169
    PHD_SF; PHD finger superfamily
  4. NM_182935.4NP_891980.1  myelin-associated oligodendrocyte basic protein isoform c

    See identical proteins and their annotated locations for NP_891980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC092058, DA343382
    Consensus CDS
    CCDS2687.1
    UniProtKB/TrEMBL
    A0A0S2Z3W1
    Related
    ENSP00000373261.3, ENST00000383754.7
    Conserved Domains (1) summary
    cl22851
    Location:173
    PHD_SF; PHD finger superfamily

RNA

  1. NR_003090.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092058, D28113, DA343382
  2. NR_103504.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site at an internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092058, D28113, DA343382
  3. NR_103505.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two alternate splice sites at an internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092058, D28113, D28114, DA343382
  4. NR_103506.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC092058, DA287397, DA343382

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    39467680..39529497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    39480633..39542424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)