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RPSA ribosomal protein SA [ Homo sapiens (human) ]

Gene ID: 3921, updated on 5-Sep-2021

Summary

Official Symbol
RPSAprovided by HGNC
Official Full Name
ribosomal protein SAprovided by HGNC
Primary source
HGNC:HGNC:6502
See related
Ensembl:ENSG00000168028 MIM:150370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SA; LBP; LRP; p40; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 792.7), lymph node (RPKM 583.0) and 25 other tissues See more
Orthologs
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Genomic context

See RPSA in Genome Data Viewer
Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (39406720..39412542)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39448211..39454033)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377644 Neighboring gene uncharacterized LOC105377037 Neighboring gene solute carrier family 25 member 38 Neighboring gene small nucleolar RNA, H/ACA box 6 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene uncharacterized LOC107986075 Neighboring gene uncharacterized LOC105377038

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein SA (RPSA), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 
enables laminin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translation IC
Inferred by Curator
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein SA
Names
37 kDa laminin receptor
37/67 kDa laminin receptor
67 kDa laminin receptor
colon carcinoma laminin-binding protein
laminin receptor 1 (67kD, ribosomal protein SA)
laminin-binding protein precursor p40
multidrug resistance-associated protein MGr1-Ag
small ribosomal subunit protein uS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033234.1 RefSeqGene

    Range
    5008..10830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_735

mRNA and Protein(s)

  1. NM_001304288.2NP_001291217.1  40S ribosomal protein SA isoform 2

    See identical proteins and their annotated locations for NP_001291217.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is longer compared to isoform 1.
    Source sequence(s)
    BC070263, BC071968, BM999786, X15005
    Consensus CDS
    CCDS77723.1
    UniProtKB/Swiss-Prot
    P08865
    UniProtKB/TrEMBL
    A0A0C4DG17
    Related
    ENSP00000389351.1, ENST00000443003.2
    Conserved Domains (1) summary
    PTZ00254
    Location:1255
    PTZ00254; 40S ribosomal protein SA; Provisional
  2. NM_002295.6NP_002286.2  40S ribosomal protein SA isoform 1

    See identical proteins and their annotated locations for NP_002286.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC070263, BC071968, BM999786
    Consensus CDS
    CCDS2686.1
    UniProtKB/Swiss-Prot
    P08865
    UniProtKB/TrEMBL
    A0A024R2P0
    Related
    ENSP00000346067.4, ENST00000301821.11
    Conserved Domains (1) summary
    PTZ00254
    Location:1250
    PTZ00254; 40S ribosomal protein SA; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    39406720..39412542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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