Acsl5 acyl-CoA synthetase long-chain family member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acsl5provided by MGI
Official Full Name: acyl-CoA synthetase long-chain family member 5provided by MGI
Primary source: MGI:MGI:1919129
See related: Ensembl:ENSMUSG00000024981 AllianceGenome:MGI:1919129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACS2; ACS5; Facl5; 1700030F05Rik
Summary: Enables long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E18 (RPKM 62.0), large intestine adult (RPKM 51.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.3 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (55240298..55285060)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (55251861..55296628)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates postprandial GLP-1 & PYY secretion, reduces food intake, and protects against diet-induced obesity.
Title: Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates postprandial GLP-1 & PYY secretion, reduces food intake, and protects against diet-induced obesity.
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
Title: Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.
Title: Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption.
Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Acsl5 (e-PCR), detects polymorphism
- UniSTS:527238

Acsl5 (e-PCR), detects polymorphism
- UniSTS:502705

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables arachidonate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oleoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables oleoyl-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-chain fatty acid import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: long-chain-fatty-acid--CoA ligase 5

Names: LACS 5; arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 5; long-chain acyl-CoA synthetase 5

NP_082252.1

EC 6.2.1.15

EC 6.2.1.3

XP_006527241.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027976.2 → NP_082252.1 long-chain-fatty-acid--CoA ligase 5

See identical proteins and their annotated locations for NP_082252.1

Status: VALIDATED

Source sequence(s)

AC133100, AI838021, BC031544

Consensus CDS

CCDS29908.1

UniProtKB/Swiss-Prot

Q8JZR0

UniProtKB/TrEMBL

Q3UC67, Q3UKS0

Related

ENSMUSP00000046585.5, ENSMUST00000043150.6

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

55240298..55285060

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527178.4 → XP_006527241.1 long-chain-fatty-acid--CoA ligase 5 isoform X1

See identical proteins and their annotated locations for XP_006527241.1

UniProtKB/Swiss-Prot

Q8JZR0

UniProtKB/TrEMBL

Q3UC67, Q3UKS0

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)