Format

Send to:

Choose Destination

ACSL5 acyl-CoA synthetase long chain family member 5 [ Homo sapiens (human) ]

Gene ID: 51703, updated on 24-Nov-2020

Summary

Official Symbol
ACSL5provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 5provided by HGNC
Primary source
HGNC:HGNC:16526
See related
Ensembl:ENSG00000197142 MIM:605677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS2; ACS5; FACL5
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues See more
Orthologs

Genomic context

See ACSL5 in Genome Data Viewer
Location:
10q25.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (112374116..112428376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (114133916..114188138)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2531 Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13267 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene microRNA 4295

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Depletion of the ACSL5 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of long-chain fatty acid import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase 5
Names
FACL5 for fatty acid coenzyme A ligase 5
LACS 5
arachidonate--CoA ligase
fatty acid coenzyme A ligase 5
fatty-acid-Coenzyme A ligase, long-chain 5
long-chain acyl-CoA synthetase 5
long-chain fatty acid coenzyme A ligase 5
NP_001373966.1
NP_057318.2
NP_976313.1
NP_976314.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387037.1NP_001373966.1  long-chain-fatty-acid--CoA ligase 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL157786
  2. NM_016234.4NP_057318.2  long-chain-fatty-acid--CoA ligase 5 isoform a

    See identical proteins and their annotated locations for NP_057318.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK024932, AL708480, AY358520
    Consensus CDS
    CCDS7572.1
    UniProtKB/Swiss-Prot
    Q9ULC5
    Related
    ENSP00000348429.1, ENST00000356116.5
    Conserved Domains (2) summary
    PLN02736
    Location:127737
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:157734
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  3. NM_203379.2NP_976313.1  long-chain-fatty-acid--CoA ligase 5 isoform b

    See identical proteins and their annotated locations for NP_976313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (b) that has a shorter N-terminus compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK000339, AK024932, AL157786, AY358520, CF595490
    Consensus CDS
    CCDS7573.1
    UniProtKB/Swiss-Prot
    Q9ULC5
    Related
    ENSP00000346680.4, ENST00000354655.8
    Conserved Domains (1) summary
    cd05927
    Location:101678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  4. NM_203380.2NP_976314.1  long-chain-fatty-acid--CoA ligase 5 isoform b

    See identical proteins and their annotated locations for NP_976314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (b) that has a shorter N-terminus compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK024932, AL708480, AY358520, CD689921
    Consensus CDS
    CCDS7573.1
    UniProtKB/Swiss-Prot
    Q9ULC5
    Related
    ENSP00000376796.1, ENST00000393081.5
    Conserved Domains (1) summary
    cd05927
    Location:101678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    112374116..112428376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center