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SLURP2 secreted LY6/PLAUR domain containing 2 [ Homo sapiens (human) ]

Gene ID: 432355, updated on 13-May-2022

Summary

Official Symbol
SLURP2provided by HGNC
Official Full Name
secreted LY6/PLAUR domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25549
See related
Ensembl:ENSG00000283992 AllianceGenome:HGNC:25549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLURP-2
Summary
This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]
Orthologs
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Genomic context

See SLURP2 in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142764338..142769828, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143907780..143913270, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143845756..143851246, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene secreted LY6/PLAUR domain containing 1 Neighboring gene LY6/PLAUR domain containing 2 Neighboring gene uncharacterized LOC124902033 Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene Ly6/neurotoxin 1 Neighboring gene lymphocyte antigen 6 family member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Readthrough LYNX1-SLURP2

Readthrough gene: LYNX1-SLURP2, Included gene: LYNX1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetylcholine receptor regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in anchored component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
secreted Ly-6/uPAR domain-containing protein 2
Names
secreted LY6/PLAUR domain-containing protein 2
secreted Ly-6/uPAR-related protein 2
secreted Ly6/uPAR related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356372.2NP_001343301.1  secreted Ly-6/uPAR domain-containing protein 2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB081838, AC083841, AY358417
    Related
    ENSP00000428465.1, ENST00000521396.1
  2. NM_177458.3NP_803253.1  secreted Ly-6/uPAR domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_803253.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB081838, AC083841, AY358417
    Consensus CDS
    CCDS34952.1
    UniProtKB/Swiss-Prot
    P0DP57
    Related
    ENSP00000319846.7, ENST00000317543.12
    Conserved Domains (1) summary
    cd00117
    Location:2497
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142764338..142769828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143907780..143913270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)