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CXCL9 C-X-C motif chemokine ligand 9 [ Homo sapiens (human) ]

Gene ID: 4283, updated on 4-Oct-2020

Summary

Official Symbol
CXCL9provided by HGNC
Official Full Name
C-X-C motif chemokine ligand 9provided by HGNC
Primary source
HGNC:HGNC:7098
See related
Ensembl:ENSG00000138755 MIM:601704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMK; MIG; Humig; SCYB9; crg-10
Summary
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded is thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Biased expression in lymph node (RPKM 167.1), appendix (RPKM 44.1) and 5 other tissues See more
Orthologs

Genomic context

See CXCL9 in Genome Data Viewer
Location:
4q21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (76001275..76007509, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76922623..76928641, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene N-acylethanolamine acid amidase Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene ADP-ribosyltransferase 3 (inactive) Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene C-X-C motif chemokine ligand 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication is enhanced by CXCL9 expression due to it activating CD4+ T cells as shown through antibody inhibition of CXCL9 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and downregulates the expression of CXCL9 in peptide-treated PBMCs PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of chemokine (C-X-C motif) ligand 9 (CXCL9; HuMIG) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including HuMIG, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CXCR3 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
defense response TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-X-C motif chemokine 9
Names
chemokine (C-X-C motif) ligand 9
gamma-interferon-induced monokine
monokine induced by gamma interferon
monokine induced by interferon-gamma
small-inducible cytokine B9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002416.3NP_002407.1  C-X-C motif chemokine 9 precursor

    See identical proteins and their annotated locations for NP_002407.1

    Status: REVIEWED

    Source sequence(s)
    AC112719, BC042178, DB141449, X72755
    Consensus CDS
    CCDS34014.1
    UniProtKB/Swiss-Prot
    Q07325
    Related
    ENSP00000354901.4, ENST00000264888.6
    Conserved Domains (1) summary
    cd00273
    Location:2890
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    76001275..76007509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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