U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MELTF melanotransferrin [ Homo sapiens (human) ]

Gene ID: 4241, updated on 22-Sep-2022

Summary

Official Symbol
MELTFprovided by HGNC
Official Full Name
melanotransferrinprovided by HGNC
Primary source
HGNC:HGNC:7037
See related
Ensembl:ENSG00000163975 MIM:155750; AllianceGenome:HGNC:7037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTf; MFI2; MTF1; CD228; MAP97
Summary
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in salivary gland (RPKM 9.5), kidney (RPKM 5.4) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MELTF in Genome Data Viewer
Location:
3q29
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (197001740..197029817, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199727923..199756006, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196728611..196756688, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein SA-like Neighboring gene Sharpr-MPRA regulatory region 2091 Neighboring gene ribosomal protein SA pseudogene 30 Neighboring gene MELTF antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:196758105-196759304 Neighboring gene discs large MAGUK scaffold protein 1 Neighboring gene microRNA 4797

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of MELTF PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4856, FLJ38863

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables iron ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
melanotransferrin
Names
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
membrane-bound transferrin-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005929.6NP_005920.2  melanotransferrin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005920.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1), as compared to variant 2.
    Source sequence(s)
    AA442552, AC068302, AH002920, BQ447289
    Consensus CDS
    CCDS3325.1
    UniProtKB/Swiss-Prot
    P08582, Q9BQE2
    Related
    ENSP00000296350.5, ENST00000296350.10
    Conserved Domains (2) summary
    smart00094
    Location:367706
    TR_FER; Transferrin
    pfam00405
    Location:23357
    Transferrin
  2. NM_033316.4NP_201573.1  melanotransferrin isoform 2 precursor

    See identical proteins and their annotated locations for NP_201573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs from variant 1 in the central coding region, resulting in a frameshift. The encoded isoform (2) has a truncated and distinct C-terminus and lacks the propeptide compared to isoform 1.
    Source sequence(s)
    AC068302, AU099352, BC071910
    Consensus CDS
    CCDS3326.1
    UniProtKB/Swiss-Prot
    P08582
    UniProtKB/TrEMBL
    Q53XS6
    Related
    ENSP00000296351.4, ENST00000296351.8
    Conserved Domains (1) summary
    cl26270
    Location:23301
    Transferrin; Transferrin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    197001740..197029817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448150.1XP_047304106.1  melanotransferrin isoform X3

  2. XM_006713643.4XP_006713706.2  melanotransferrin isoform X2

    Conserved Domains (4) summary
    smart00094
    Location:367732
    TR_FER; Transferrin
    cd13529
    Location:23355
    PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily
    pfam00405
    Location:23357
    Transferrin; Transferrin
    cl21456
    Location:367727
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_011512850.3XP_011511152.1  melanotransferrin isoform X1

    Conserved Domains (3) summary
    smart00094
    Location:367733
    TR_FER; Transferrin
    cd13529
    Location:23355
    PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily
    pfam00405
    Location:23357
    Transferrin; Transferrin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    199727923..199756006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)