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MEF2A myocyte enhancer factor 2A [ Homo sapiens (human) ]

Gene ID: 4205, updated on 24-Nov-2020

Summary

Official Symbol
MEF2Aprovided by HGNC
Official Full Name
myocyte enhancer factor 2Aprovided by HGNC
Primary source
HGNC:HGNC:6993
See related
Ensembl:ENSG00000068305 MIM:600660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mef2; ADCAD1; RSRFC4; RSRFC9
Summary
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See MEF2A in Genome Data Viewer
Location:
15q26.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (99565417..99716488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (100106133..100256688)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371019 Neighboring gene ribosomal protein L7 pseudogene 5 Neighboring gene LysM domain containing 4 Neighboring gene uncharacterized LOC105371020 Neighboring gene RNA, 7SL, cytoplasmic 484, pseudogene Neighboring gene dynamin 1 pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
tat HIV-1 Tat increases levels of phosphorylated MEF2 in human neuronal cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK5 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
mitochondrial genome maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion distribution ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle organ development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle hypertrophy IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
ventricular cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISA
Inferred from Sequence Alignment
more info
 
chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myocyte-specific enhancer factor 2A
Names
MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
serum response factor-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016443.2 RefSeqGene

    Range
    5057..155561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130926.3NP_001124398.1  myocyte-specific enhancer factor 2A isoform 2

    See identical proteins and their annotated locations for NP_001124398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon and a 5' non-coding exon, compared to transcript variant 6. These differences result in a shorter isoform (2), compared to isoform 5. Variants 2 and 5 both encode isoform 2.
    Source sequence(s)
    AC022692, AK291835, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A0A0S2Z4N0, A8K720
    Related
    ENSP00000337202.7, ENST00000338042.10
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. NM_001130927.3NP_001124399.1  myocyte-specific enhancer factor 2A isoform 3

    See identical proteins and their annotated locations for NP_001124399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame 5' coding exon and a 5' non-coding exon, compared to transcript variant 6. These differences result in a shorter isoform (3), compared to isoform 5.
    Source sequence(s)
    AC022692, AK294207, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS45363.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z4N0
    Related
    ENSP00000454120.1, ENST00000558812.5
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  3. NM_001130928.2NP_001124400.1  myocyte-specific enhancer factor 2A isoform 4

    See identical proteins and their annotated locations for NP_001124400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple, in-frame coding exons, compared to transcript variant 6. These differences result in a shorter isoform (4), compared to isoform 5. The 5' UTR of this transcript variant is undefined.
    Source sequence(s)
    AC022692, BC053871, BM664145, KU178183
    Consensus CDS
    CCDS58401.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z4C8, A0A0S2Z4N0
    Related
    ENSP00000399460.2, ENST00000449277.6
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  4. NM_001171894.3NP_001165365.1  myocyte-specific enhancer factor 2A isoform 2

    See identical proteins and their annotated locations for NP_001165365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon and contains an additional 5' non-coding exon, compared to transcript variant 6. These differences result in a shorter isoform (2), compared to isoform 5. Variants 2 and 5 both encode isoform 2.
    Source sequence(s)
    AB208985, AC022692, BM664145, KU178183
    Consensus CDS
    CCDS53978.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z417, A0A0S2Z4N0
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  5. NM_001319206.2NP_001306135.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (5).
    Source sequence(s)
    AB208985, AC022692, AL831995, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS81920.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z4N0
    Related
    ENSP00000453095.1, ENST00000557942.5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  6. NM_001352614.2NP_001339543.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  7. NM_001352615.2NP_001339544.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  8. NM_001352616.2NP_001339545.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  9. NM_001352617.2NP_001339546.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  10. NM_001352618.2NP_001339547.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  11. NM_001365201.1NP_001352130.1  myocyte-specific enhancer factor 2A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  12. NM_001365202.1NP_001352131.1  myocyte-specific enhancer factor 2A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  13. NM_001365203.1NP_001352132.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  14. NM_001365204.1NP_001352133.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  15. NM_001365205.1NP_001352134.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  16. NM_001365206.1NP_001352135.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  17. NM_001365207.1NP_001352136.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  18. NM_001365208.1NP_001352137.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Related
    ENSP00000453441.1, ENST00000557785.5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  19. NM_001365209.1NP_001352138.1  myocyte-specific enhancer factor 2A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  20. NM_001365210.2NP_001352139.1  myocyte-specific enhancer factor 2A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  21. NM_001365211.2NP_001352140.1  myocyte-specific enhancer factor 2A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  22. NM_005587.4NP_005578.2  myocyte-specific enhancer factor 2A isoform 1

    See identical proteins and their annotated locations for NP_005578.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks multiple, in-frame coding exons and uses an alternate coding exon, compared to transcript variant 6. These differences result in a shorter isoform (1), compared to isoform 5.
    Source sequence(s)
    AC022692, BC013437, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS45362.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z454, A0A0S2Z4N0
    Related
    ENSP00000346389.5, ENST00000354410.9
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    99565417..99716488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521579.2XP_011519881.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519881.1

    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. XM_011521572.2XP_011519874.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519874.1

    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  3. XM_017022202.1XP_016877691.1  myocyte-specific enhancer factor 2A isoform X15

  4. XM_017022196.1XP_016877685.1  myocyte-specific enhancer factor 2A isoform X11

  5. XM_017022200.1XP_016877689.1  myocyte-specific enhancer factor 2A isoform X14

  6. XM_011521587.2XP_011519889.1  myocyte-specific enhancer factor 2A isoform X10

    See identical proteins and their annotated locations for XP_011519889.1

    UniProtKB/TrEMBL
    A0A0S2Z4C8
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  7. XM_011521585.2XP_011519887.1  myocyte-specific enhancer factor 2A isoform X7

    Conserved Domains (2) summary
    pfam12347
    Location:3088
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:218
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  8. XM_011521582.2XP_011519884.1  myocyte-specific enhancer factor 2A isoform X2

    See identical proteins and their annotated locations for XP_011519884.1

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z453
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  9. XM_011521590.2XP_011519892.1  myocyte-specific enhancer factor 2A isoform X16

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  10. XM_005254916.3XP_005254973.1  myocyte-specific enhancer factor 2A isoform X17

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149232
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  11. XM_017022198.2XP_016877687.1  myocyte-specific enhancer factor 2A isoform X12

  12. XM_017022201.1XP_016877690.1  myocyte-specific enhancer factor 2A isoform X14

  13. XM_017022195.1XP_016877684.1  myocyte-specific enhancer factor 2A isoform X9

    Conserved Domains (3) summary
    pfam11597
    Location:61170
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:3084
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:218
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  14. XM_011521573.2XP_011519875.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519875.1

    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  15. XM_017022197.2XP_016877686.1  myocyte-specific enhancer factor 2A isoform X12

  16. XM_011521577.2XP_011519879.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519879.1

    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  17. XM_011521578.2XP_011519880.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519880.1

    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  18. XM_017022199.1XP_016877688.1  myocyte-specific enhancer factor 2A isoform X13

  19. XM_017022191.1XP_016877680.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z453
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RNA

  1. XR_001751289.1 RNA Sequence

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