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MEF2A myocyte enhancer factor 2A [ Homo sapiens (human) ]

Gene ID: 4205, updated on 2-Oct-2018

Summary

Official Symbol
MEF2Aprovided by HGNC
Official Full Name
myocyte enhancer factor 2Aprovided by HGNC
Primary source
HGNC:HGNC:6993
See related
Ensembl:ENSG00000068305 MIM:600660; Vega:OTTHUMG00000171937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mef2; ADCAD1; RSRFC4; RSRFC9
Summary
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See MEF2A in Genome Data Viewer
Location:
15q26.3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (99565547..99716488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (100106133..100256688)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371019 Neighboring gene ribosomal protein L7 pseudogene 5 Neighboring gene LysM domain containing 4 Neighboring gene uncharacterized LOC105371020 Neighboring gene RNA, 7SL, cytoplasmic 484, pseudogene Neighboring gene dynamin 1 pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
tat HIV-1 Tat increases levels of phosphorylated MEF2 in human neuronal cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • CDO in myogenesis, organism-specific biosystem (from REACTOME)
    CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
  • Cardiac Hypertrophic Response, organism-specific biosystem (from WikiPathways)
    Cardiac Hypertrophic Response, organism-specific biosystemIntegrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiolo...
  • Cell Differentiation - Index, organism-specific biosystem (from WikiPathways)
    Cell Differentiation - Index, organism-specific biosystemProteins and miRNAs associated with major cell type differentiation pathways.
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • ERK/MAPK targets, organism-specific biosystem (from REACTOME)
    ERK/MAPK targets, organism-specific biosystemERK/MAPK kinases have a number of targets within the nucleus, usually transcription factors or other kinases. The best known targets, ELK1, ETS1, ATF2, MITF, MAPKAPK2, MSK1, RSK1/2/3 and MEF2 are ann...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
    MAP kinase activation in TLR cascade, organism-specific biosystemThe mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascad...
  • MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
    MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystemMAPKs are protein kinases that, once activated, phosphorylate their specific cytosolic or nuclear substrates at serine and/or threonine residues. Such phosphorylation events can either positively or ...
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
  • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • Myogenesis, organism-specific biosystem (from REACTOME)
    Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Nuclear Events (kinase and transcription factor activation), organism-specific biosystem (from REACTOME)
    Nuclear Events (kinase and transcription factor activation), organism-specific biosystemAn important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene express...
  • SRF and miRs in Smooth Muscle Differentiation and Proliferation, organism-specific biosystem (from WikiPathways)
    SRF and miRs in Smooth Muscle Differentiation and Proliferation, organism-specific biosystemSmooth muscle cells exhibit a unique plasticity, in that they are able to oscillate between proliferative and more quiescent, differentiated states. These two states are determined, in part, by a net...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • miRs in Muscle Cell Differentiation, organism-specific biosystem (from WikiPathways)
    miRs in Muscle Cell Differentiation, organism-specific biosystem
    miRs in Muscle Cell Differentiation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK5 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
mitochondrial genome maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion distribution ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle organ development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle hypertrophy IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
ventricular cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myocyte-specific enhancer factor 2A
Names
MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
serum response factor-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016443.2 RefSeqGene

    Range
    5001..155561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130926.2NP_001124398.1  myocyte-specific enhancer factor 2A isoform 2

    See identical proteins and their annotated locations for NP_001124398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon and a 5' non-coding exon, compared to transcript variant 6. These differences result in a shorter isoform (2), compared to isoform 5. Variants 2 and 5 both encode isoform 2.
    Source sequence(s)
    AC022692, AK291835, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A0A0S2Z4N0, A8K720
    Related
    ENSP00000337202.7, ENST00000338042.10
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. NM_001130927.2NP_001124399.1  myocyte-specific enhancer factor 2A isoform 3

    See identical proteins and their annotated locations for NP_001124399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame 5' coding exon and a 5' non-coding exon, compared to transcript variant 6. These differences result in a shorter isoform (3), compared to isoform 5.
    Source sequence(s)
    AC022692, AK294207, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS45363.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z4N0
    Related
    ENSP00000454120.1, OTTHUMP00000247217, ENST00000558812.5, OTTHUMT00000415982
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  3. NM_001130928.2NP_001124400.1  myocyte-specific enhancer factor 2A isoform 4

    See identical proteins and their annotated locations for NP_001124400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple, in-frame coding exons, compared to transcript variant 6. These differences result in a shorter isoform (4), compared to isoform 5. The 5' UTR of this transcript variant is undefined.
    Source sequence(s)
    AC022692, BC053871, BM664145, KU178183
    Consensus CDS
    CCDS58401.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z4C8, A0A0S2Z4N0
    Related
    ENSP00000399460.2, OTTHUMP00000247220, ENST00000449277.6, OTTHUMT00000415987
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  4. NM_001171894.2NP_001165365.1  myocyte-specific enhancer factor 2A isoform 2

    See identical proteins and their annotated locations for NP_001165365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon and contains an additional 5' non-coding exon, compared to transcript variant 6. These differences result in a shorter isoform (2), compared to isoform 5. Variants 2 and 5 both encode isoform 2.
    Source sequence(s)
    AB208985, AC022692, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS53978.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z417, A0A0S2Z4N0
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  5. NM_001319206.1NP_001306135.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (5).
    Source sequence(s)
    AB208985, AC022692, AL831995, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS81920.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z4N0
    Related
    ENSP00000453095.1, OTTHUMP00000247221, ENST00000557942.5, OTTHUMT00000415988
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  6. NM_001352614.1NP_001339543.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  7. NM_001352615.1NP_001339544.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  8. NM_001352616.1NP_001339545.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  9. NM_001352617.1NP_001339546.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  10. NM_001352618.1NP_001339547.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  11. NM_001365201.1NP_001352130.1  myocyte-specific enhancer factor 2A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  12. NM_001365202.1NP_001352131.1  myocyte-specific enhancer factor 2A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  13. NM_001365203.1NP_001352132.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  14. NM_001365204.1NP_001352133.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  15. NM_001365205.1NP_001352134.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  16. NM_001365206.1NP_001352135.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  17. NM_001365207.1NP_001352136.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  18. NM_001365208.1NP_001352137.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  19. NM_001365209.1NP_001352138.1  myocyte-specific enhancer factor 2A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  20. NM_001365210.1NP_001352139.1  myocyte-specific enhancer factor 2A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  21. NM_001365211.1NP_001352140.1  myocyte-specific enhancer factor 2A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
  22. NM_005587.3NP_005578.2  myocyte-specific enhancer factor 2A isoform 1

    See identical proteins and their annotated locations for NP_005578.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks multiple, in-frame coding exons and uses an alternate coding exon, compared to transcript variant 6. These differences result in a shorter isoform (1), compared to isoform 5.
    Source sequence(s)
    AC022692, BC013437, BM664145, DA778137, KU178183
    Consensus CDS
    CCDS45362.1
    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z454, A0A0S2Z4N0
    Related
    ENSP00000346389.5, OTTHUMP00000247216, ENST00000354410.9, OTTHUMT00000415980
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    99565547..99716488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521579.2XP_011519881.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519881.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. XM_011521572.2XP_011519874.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519874.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  3. XM_017022202.1XP_016877691.1  myocyte-specific enhancer factor 2A isoform X15

  4. XM_017022196.1XP_016877685.1  myocyte-specific enhancer factor 2A isoform X11

  5. XM_017022200.1XP_016877689.1  myocyte-specific enhancer factor 2A isoform X14

  6. XM_005254915.2XP_005254972.1  myocyte-specific enhancer factor 2A isoform X6

    See identical proteins and their annotated locations for XP_005254972.1

    UniProtKB/TrEMBL
    A0A0S2Z417
    Related
    ENSP00000453441.1, OTTHUMP00000247218, ENST00000557785.5, OTTHUMT00000415985
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  7. XM_011521571.3XP_011519873.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519873.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  8. XM_011521586.2XP_011519888.1  myocyte-specific enhancer factor 2A isoform X8

    See identical proteins and their annotated locations for XP_011519888.1

    UniProtKB/Swiss-Prot
    Q02078
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  9. XM_011521587.2XP_011519889.1  myocyte-specific enhancer factor 2A isoform X10

    See identical proteins and their annotated locations for XP_011519889.1

    UniProtKB/TrEMBL
    A0A0S2Z4C8
    Conserved Domains (2) summary
    pfam12347
    Location:2982
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:225
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  10. XM_011521585.2XP_011519887.1  myocyte-specific enhancer factor 2A isoform X7

    Conserved Domains (2) summary
    pfam12347
    Location:3088
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:218
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  11. XM_017022204.1XP_016877693.1  myocyte-specific enhancer factor 2A isoform X19

  12. XM_017022203.1XP_016877692.1  myocyte-specific enhancer factor 2A isoform X18

  13. XM_011521582.2XP_011519884.1  myocyte-specific enhancer factor 2A isoform X2

    See identical proteins and their annotated locations for XP_011519884.1

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z453
    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:129238
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  14. XM_011521581.3XP_011519883.1  myocyte-specific enhancer factor 2A isoform X2

    See identical proteins and their annotated locations for XP_011519883.1

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z453
    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:129238
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  15. XM_011521590.2XP_011519892.1  myocyte-specific enhancer factor 2A isoform X16

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  16. XM_005254916.3XP_005254973.1  myocyte-specific enhancer factor 2A isoform X17

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149232
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  17. XM_017022198.2XP_016877687.1  myocyte-specific enhancer factor 2A isoform X12

  18. XM_011521583.2XP_011519885.1  myocyte-specific enhancer factor 2A isoform X3

    See identical proteins and their annotated locations for XP_011519885.1

    UniProtKB/TrEMBL
    A0A0S2Z4N0
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  19. XM_011521576.2XP_011519878.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519878.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  20. XM_017022190.1XP_016877679.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z453
    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:129238
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  21. XM_017022194.1XP_016877683.1  myocyte-specific enhancer factor 2A isoform X4

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z454
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  22. XM_017022201.1XP_016877690.1  myocyte-specific enhancer factor 2A isoform X14

  23. XM_017022192.1XP_016877681.1  myocyte-specific enhancer factor 2A isoform X5

    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  24. XM_017022195.1XP_016877684.1  myocyte-specific enhancer factor 2A isoform X9

    Conserved Domains (3) summary
    pfam11597
    Location:61170
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:3084
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:218
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  25. XM_011521573.2XP_011519875.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519875.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  26. XM_017022197.2XP_016877686.1  myocyte-specific enhancer factor 2A isoform X12

  27. XM_011521577.2XP_011519879.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519879.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  28. XM_011521578.2XP_011519880.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519880.1

    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:149242
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  29. XM_017022199.1XP_016877688.1  myocyte-specific enhancer factor 2A isoform X13

  30. XM_017022191.1XP_016877680.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    Q02078
    UniProtKB/TrEMBL
    A0A0S2Z453
    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:129238
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RNA

  1. XR_001751289.1 RNA Sequence

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