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DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 [ Homo sapiens (human) ]

Gene ID: 4189, updated on 7-Dec-2018

Summary

Official Symbol
DNAJB9provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B9provided by HGNC
Primary source
HGNC:HGNC:6968
See related
Ensembl:ENSG00000128590 MIM:602634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDG1; ERdj4; MDG-1; MST049; MSTP049
Summary
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in thyroid (RPKM 55.6), adrenal (RPKM 35.9) and 25 other tissues See more
Orthologs

Genomic context

See DNAJB9 in Genome Data Viewer
Location:
7q31.1; 14q24.2-q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (108569745..108574850)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (108210189..108215294)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene neuronal cell adhesion molecule Neighboring gene RNA, U7 small nuclear 83 pseudogene Neighboring gene patatin like phospholipase domain containing 8 Neighboring gene ribosomal protein L7 pseudogene 32 Neighboring gene uncharacterized LOC105375448 Neighboring gene THAP domain containing 5 Neighboring gene sorbitol dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.
NHGRI GWA Catalog

Pathways from BioSystems

  • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
    IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
    XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564F1862

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of IRE1-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 9
Names
DnaJ (Hsp40) homolog, subfamily B, member 9
ER-resident protein ERdj4
endoplasmic reticulum DNA J domain-containing protein 4
endoplasmic reticulum DnaJ homolog 4
microvascular endothelial differentiation gene 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012328.3NP_036460.1  dnaJ homolog subfamily B member 9 precursor

    See identical proteins and their annotated locations for NP_036460.1

    Status: REVIEWED

    Source sequence(s)
    AB026908, DA202575
    Consensus CDS
    CCDS5752.1
    UniProtKB/Swiss-Prot
    Q9UBS3
    UniProtKB/TrEMBL
    Q6FIF1
    Related
    ENSP00000249356.3, ENST00000249356.3
    Conserved Domains (1) summary
    cl28246
    Location:26136
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    108569745..108574850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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