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Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 [ Mus musculus (house mouse) ]

Gene ID: 27362, updated on 8-Feb-2024

Summary

Official Symbol
Dnajb9provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B9provided by MGI
Primary source
MGI:MGI:1351618
See related
Ensembl:ENSMUSG00000014905 AllianceGenome:MGI:1351618
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdg1; mDj7; ERdj4
Summary
Enables Hsp70 protein binding activity and chaperone binding activity. Involved in B cell differentiation; positive regulation of immunoglobulin production; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human DNAJB9 (DnaJ heat shock protein family (Hsp40) member B9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 14.5), testis adult (RPKM 10.5) and 24 other tissues See more
Orthologs
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Genomic context

See Dnajb9 in Genome Data Viewer
Location:
12 B2; 12 20.71 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (44252680..44256851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (44205897..44210068, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32023 Neighboring gene STARR-seq mESC enhancer starr_32024 Neighboring gene predicted gene, 46349 Neighboring gene STARR-seq mESC enhancer starr_32025 Neighboring gene STARR-seq mESC enhancer starr_32026 Neighboring gene STARR-seq mESC enhancer starr_32027 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene microRNA 5627 Neighboring gene nuclear assembly factor 1 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 9
Names
DNA j protein b9
DnaJ (Hsp40) homolog, subfamily B, member 9
ER-resident protein ERdj4
endoplasmic reticulum DNA J domain-containing protein 4
microvascular endothelial differentiation gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013760.4NP_038788.2  dnaJ homolog subfamily B member 9 precursor

    See identical proteins and their annotated locations for NP_038788.2

    Status: PROVISIONAL

    Source sequence(s)
    AK005475
    Consensus CDS
    CCDS25897.1
    UniProtKB/Swiss-Prot
    Q5D0C3, Q9DAW1, Q9QYI6
    Related
    ENSMUSP00000015049.4, ENSMUST00000015049.5
    Conserved Domains (1) summary
    pfam00226
    Location:2687
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    44252680..44256851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)