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ART1 ADP-ribosyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 417, updated on 22-Sep-2022

Summary

Official Symbol
ART1provided by HGNC
Official Full Name
ADP-ribosyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:723
See related
Ensembl:ENSG00000129744 MIM:601625; AllianceGenome:HGNC:723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RT6; ART2; ARTC1; CD296
Summary
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ART1 in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3645128..3664416)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3690584..3729789)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3666358..3685646)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+-protein-arginine ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Names
ADP-ribosyltransferase 2
ADP-ribosyltransferase C2 and C3 toxin-like 1
mono(ADP-ribosyl)transferase 1
NP_004305.2
XP_011518416.1
XP_016873252.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004314.3NP_004305.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_004305.2

    Status: REVIEWED

    Source sequence(s)
    AC060812, BC069102, S74683
    Consensus CDS
    CCDS7744.1
    UniProtKB/Swiss-Prot
    P52961, Q96KT9
    Related
    ENSP00000250693.1, ENST00000250693.2
    Conserved Domains (1) summary
    pfam01129
    Location:39274
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3645128..3664416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017763.3XP_016873252.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P52961, Q96KT9
    Conserved Domains (1) summary
    pfam01129
    Location:39274
    ART; NAD:arginine ADP-ribosyltransferase
  2. XM_011520114.4XP_011518416.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011518416.1

    UniProtKB/Swiss-Prot
    P52961, Q96KT9
    Conserved Domains (1) summary
    pfam01129
    Location:39274
    ART; NAD:arginine ADP-ribosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3690584..3729789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)