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ART1 ADP-ribosyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 417, updated on 1-Jun-2020

Summary

Official Symbol
ART1provided by HGNC
Official Full Name
ADP-ribosyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:723
See related
Ensembl:ENSG00000129744 MIM:601625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RT6; ART2; ARTC1; CD296
Summary
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ART1 in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (3645110..3665516)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3663487..3685844)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene RNA, U6 small nuclear 1143, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidyl-arginine ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Names
ADP-ribosyltransferase 2
ADP-ribosyltransferase C2 and C3 toxin-like 1
mono(ADP-ribosyl)transferase 1
NP_004305.2
XP_011518416.1
XP_016873252.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004314.3NP_004305.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_004305.2

    Status: REVIEWED

    Source sequence(s)
    AC060812, BC069102, S74683
    Consensus CDS
    CCDS7744.1
    UniProtKB/Swiss-Prot
    P52961
    Related
    ENSP00000250693.1, ENST00000250693.2
    Conserved Domains (1) summary
    pfam01129
    Location:39274
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    3645110..3665516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017763.2XP_016873252.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P52961
    Conserved Domains (1) summary
    pfam01129
    Location:39274
    ART; NAD:arginine ADP-ribosyltransferase
  2. XM_011520114.3XP_011518416.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011518416.1

    UniProtKB/Swiss-Prot
    P52961
    Conserved Domains (1) summary
    pfam01129
    Location:39274
    ART; NAD:arginine ADP-ribosyltransferase
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