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mapk11 mitogen-activated protein kinase 11 [ Danio rerio (zebrafish) ]

Gene ID: 415185, updated on 25-Apr-2024

Summary

Official Symbol
mapk11provided by ZNC
Official Full Name
mitogen-activated protein kinase 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-75
See related
Ensembl:ENSDARG00000045836 AllianceGenome:ZFIN:ZDB-GENE-040625-75
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86905
Summary
Predicted to enable MAP kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in granule cell. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See mapk11 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5506959..5522440)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5498389..5513870)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene soluble scavenger receptor cysteine-rich domain-containing protein SSC5D-like Neighboring gene deleted in malignant brain tumors 1 protein-like Neighboring gene mitogen-activated protein kinase 12b Neighboring gene si:dkey-14d8.6

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 11
NP_001002095.1
XP_017210482.1
XP_021330662.1
XP_021330663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002095.1NP_001002095.1  mitogen-activated protein kinase 11

    See identical proteins and their annotated locations for NP_001002095.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071526
    UniProtKB/TrEMBL
    A0A8M1MZX2, Q6IQ84
    Related
    ENSDARP00000034350.5, ENSDART00000032857.7
    Conserved Domains (2) summary
    cd07878
    Location:7349
    STKc_p38beta; Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11)
    smart00220
    Location:23307
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    5506959..5522440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474987.1XP_021330662.1  mitogen-activated protein kinase 11 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PH56
    Conserved Domains (1) summary
    cl21453
    Location:21268
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017354993.2XP_017210482.1  mitogen-activated protein kinase 11 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z5A8
  3. XM_021474988.1XP_021330663.1  mitogen-activated protein kinase 11 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PUC2
    Conserved Domains (1) summary
    cl21453
    Location:1242
    PKc_like; Protein Kinases, catalytic domain