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LCN10 lipocalin 10 [ Homo sapiens (human) ]

Gene ID: 414332, updated on 11-Jun-2021

Summary

Official Symbol
LCN10provided by HGNC
Official Full Name
lipocalin 10provided by HGNC
Primary source
HGNC:HGNC:20892
See related
Ensembl:ENSG00000187922 MIM:612904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Expression
Broad expression in spleen (RPKM 4.2), endometrium (RPKM 3.9) and 19 other tissues See more
Orthologs
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Genomic context

See LCN10 in Genome Data Viewer
Location:
9q34.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136738170..136742940, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139632622..139637392, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 7 Neighboring gene small nucleolar RNA, H/ACA box 17B Neighboring gene small nucleolar RNA, H/ACA box 17A Neighboring gene uncharacterized LOC100128593 Neighboring gene lipocalin 6 Neighboring gene microRNA 6722 Neighboring gene lipocalin 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Potential readthrough

Included gene: LCN6

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
epididymal-specific lipocalin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001712.3NP_001001712.2  epididymal-specific lipocalin-10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001001712.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL355987
    Consensus CDS
    CCDS35182.2
    UniProtKB/Swiss-Prot
    Q6JVE6
    Related
    ENSP00000418491.1, ENST00000497771.6
  2. NM_001368089.1NP_001355018.1  epididymal-specific lipocalin-10 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL355987, AY301271
    Related
    ENSP00000420564.1, ENST00000474369.1
  3. NM_001368090.1NP_001355019.1  epididymal-specific lipocalin-10 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL355987, BC144441
    Related
    ENSP00000431726.1, ENST00000527229.5

RNA

  1. NR_160514.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355987, BC171741
  2. NR_160515.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355987, HY166769
  3. NR_160516.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355987, DA965366
  4. NR_160517.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355987
    Related
    ENST00000341040.11

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136738170..136742940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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