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MAT1A methionine adenosyltransferase 1A [ Homo sapiens (human) ]

Gene ID: 4143, updated on 13-Feb-2019

Summary

Official Symbol
MAT1Aprovided by HGNC
Official Full Name
methionine adenosyltransferase 1Aprovided by HGNC
Primary source
HGNC:HGNC:6903
See related
Ensembl:ENSG00000151224 MIM:610550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAT; SAMS; MATA1; SAMS1
Summary
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 313.0) See more
Orthologs

Genomic context

See MAT1A in Genome Data Viewer
Location:
10q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (80271820..80289678, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82031576..82049721, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 857 Neighboring gene ribosomal protein S12 pseudogene 2 Neighboring gene uncharacterized LOC100130698 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 4 Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene DPY30 domain containing 1 Neighboring gene DPY30 domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine adenosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
S-adenosylmethionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
methionine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylation TAS
Traceable Author Statement
more info
 
one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
selenium compound metabolic process TAS
Traceable Author Statement
more info
 
sulfur amino acid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
S-adenosylmethionine synthase isoform type-1
Names
MAT 1
MAT-I/III
S-adenosylmethionine synthetase isoform type-1
adoMet synthase 1
adoMet synthetase 1
methionine adenosyltransferase 1
methionine adenosyltransferase I, alpha
methionine adenosyltransferase I/III
NP_000420.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008083.1 RefSeqGene

    Range
    5001..22859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000429.3NP_000420.1  S-adenosylmethionine synthase isoform type-1

    See identical proteins and their annotated locations for NP_000420.1

    Status: REVIEWED

    Source sequence(s)
    BC018359, BM738684, BX496326, X69078
    Consensus CDS
    CCDS7365.1
    UniProtKB/Swiss-Prot
    Q00266
    Related
    ENSP00000361287.3, ENST00000372213.7
    Conserved Domains (1) summary
    PTZ00104
    Location:12393
    PTZ00104; S-adenosylmethionine synthase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    80271820..80289678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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